85356-68-9

Basic information

• Product Name: 1-BROMO-4-(2-IODOETHYL)BENZENE
• Synonyms: 1-BROMO-4-(2-IODOETHYL)BENZENE;2-(4-Bromophenyl)ethyliodide
• CAS NO: 85356-68-9
• Molecular Formula: C₈H₈BrI
• Molecular Weight: 310.95759
• Mol File: 85356-68-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 291.9 °C at 760 mmHg
• Flash Point: 130.3 °C
• Appearance: /
• Density: 1.977 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility: at 25 deg C (mg/L): 1.067
• CAS DataBase Reference: 1-BROMO-4-(2-IODOETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-(2-IODOETHYL)BENZENE(85356-68-9)
• EPA Substance Registry System: 1-BROMO-4-(2-IODOETHYL)BENZENE(85356-68-9)

Safety Data

• Hazardous Substances Data: 85356-68-9(Hazardous Substances Data)

Usage

General Description

The chemical 1-Bromo-4-(2-iodoethyl)benzene, also known as 2-Iodoethyl 4-bromobenzene, is an aromatic compound containing a benzene ring with a bromine atom at the 1 position and an ethyl group with an iodine atom at the 4 position. It is commonly used in organic synthesis and research as a reagent or intermediate for the preparation of various compounds. It is also used in the pharmaceutical industry for the synthesis of biologically active molecules. This chemical is flammable and should be handled and stored with care in a well-ventilated area. It is important to follow proper safety procedures and handling protocols when working with this chemical.

Upstream product

• 114369-15-2 2-(4-bromophenyl)ethyl methanesulfonate 
• 4654-39-1 4-bromophenethanol 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 1746-28-7 1-bromo-4-(2-bromoethyl)benzene 

Downstream Products

• 85356-73-6 1-Bromo-4-(3-methylene-pent-4-enyl)-benzene 
• 167504-27-0 (+/-)-5-(4'-bromophenethyl)-5,6,7,8-tetrahydroisoquinoline 
• 167504-28-1 5,5-bis(4'-bromophenethyl)-5,6,7,8-tetrahydroisoquinoline 
• 928776-08-3 4-[2-(4-bromo-phenyl)-ethyl]-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde 
• 167504-32-7 5-<2-(4-bromophenyl)ethyl>-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 845550-71-2 diethyl 2-acetamido-2-[2-(4-bromophenyl)ethyl]malonate 
• 956037-42-6 diethyl 2-[2-(4-bromophenyl)ethyl]-2-methylmalonate 
• 956037-48-2 4-(4-bromophenyl)-2-ethoxycarbonyl-2-ethylbutyric acid 
• 1112412-95-9 (5-bromo-2-ethylphenyl)furan-2-ylmethanol 
• 1289626-83-0 (+/-)-2-methyl-2-(methylsulfonyl)-4-(4'-nitrobiphenyl-4-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 1289627-00-4 {4-[4-ethoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl]phenyl}boronic acid 
• 1289627-01-5 ethyl 2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)butanoate 
• 1289626-08-9 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid 
• 1289627-03-7 2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)butanoic acid 

Relevant articles and documents

Convergent Synthesis of Immune Inhibitor IMMH002

A convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene is described with a key Suzuki-Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatography and solves the most intractable quality problem caused by a homologue by-product in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein is more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route.

Preparation method of aituomode

The invention discloses a preparation method of aituomode. Bromo-benzene is used as an initial raw material to prepare aituomode by adopting a convergent synthesis route. The yield of the preparationmethod is high, the cost is low, the amount of generated waste water, waste gas, and waste solids is low, the operation is convenient, and the application value is high.

Migratory Hydrogenation of Terminal Alkynes by Base/Cobalt Relay Catalysis

Migratory functionalization of alkenes has emerged as a powerful strategy to achieve functionalization at a distal position to the original reactive site on a hydrocarbon chain. However, an analogous protocol for alkyne substrates is yet to be developed. Herein, a base and cobalt relay catalytic process for the selective synthesis of (Z)-2-alkenes and conjugated E alkenes by migratory hydrogenation of terminal alkynes is disclosed. Mechanistic studies support a relay catalytic process involving a sequential base-catalyzed isomerization of terminal alkynes and cobalt-catalyzed hydrogenation of either 2-alkynes or conjugated diene intermediates. Notably, this practical non-noble metal catalytic system enables efficient control of the chemo-, regio-, and stereoselectivity of this transformation.