129212-21-1Relevant articles and documents
Synthesis of β-methoxyacrylate natural products based on box-Pd IIcatalyzed intermolecular methoxycarbonylation of alkynoles
Motodate, Satoshi,Kobayashi, Takuya,Fujii, Mikio,Mochida, Tomoyuki,Kusakabe, Taichi,Katoh, Shigeki,Akita, Hiroyuki,Kato, Keisuke
supporting information; experimental part, p. 2221 - 2230 (2011/06/21)
Bis(oxazoline)-palladium(II) catalyzed carbonylation of homopropargyl alcohols afforded acyclic methoxyacrylate 2 and 6-membered lactone 3a-k in good combined yield. In the case of propargyl alcohols, 5-membered lactones 3p, 3q, 16 were obtained in moderate yields. The one-pot synthesis of kawa lactones 3a, 3r, 3s and formal synthesis of dihydroxycystothiazole A and dihydroxycystothiazole C are presented. To elucidate the stereochemistry of (+)-annularin G and (-)-annularin H, the first asymmetric syntheses of these natural products were achieved.
Chiral 1,2-bis(phosphetano)benzenes: Preparation and use in the Ru- catalyzed hydrogenations of carbonyl derivatives
Marinetti, Angela,Genet, Jean-Pierre,Jus, Sebastien,Blanc, Delphine,Ratovelomanana-Vidal, Virginie
, p. 1160 - 1165 (2007/10/03)
Chiral 1,2-bis(phosphetano)benzenes are readily prepared from accessible, optically pure 1,3-diol cyclic sulfates. Their ruthenium complexes catalyze the enantioselective hydrogenations of functionalized carbonyls with moderate-to-high enantiomeric excesses. High levels of diastereo- and enantioselectivity are achieved, especially in the hydrogenation of β-diketones to the corresponding anti-1,3-diols.
Optically Pure 1,3-Diols from (2R,4R)- and (2S,4S)-1,2:4,5-Diepoxypentane
Rychnovsky, Scott D.,Griesgraber, George,Zeller, Sam,Skalitzky, Donald J.
, p. 5161 - 5169 (2007/10/02)
Optically pure (>97percent ee) (2R,4R)-1,2:4,5-diepoxypentane (1) and its enantiomer can be prepared in three steps from 2,4-pentanedione without the need for chromatographic purification.Diepoxide 1 is an efficient precursor to a wide variety of opticall