40630-12-4

Basic information

• Product Name: 2,4-Pentanedione, 1,5-dichloro-
• Synonyms: 2,4-Pentanedione, 1,5-dichloro-;1,5-dichloropentane-2,4-dione
• CAS NO: 40630-12-4
• Molecular Formula: C₅H₆Cl₂O₂
• Molecular Weight: 169.01
• Mol File: 40630-12-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Pentanedione, 1,5-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pentanedione, 1,5-dichloro-(40630-12-4)
• EPA Substance Registry System: 2,4-Pentanedione, 1,5-dichloro-(40630-12-4)

Safety Data

• Hazardous Substances Data: 40630-12-4(Hazardous Substances Data)

Usage

Description

2,4-Pentanedione, 1,5-dichlorois a chemical compound with the molecular formula C5H6Cl2O. It is a derivative of pentanedione, a compound commonly used in the synthesis of various organic compounds. 2,4-Pentanedione, 1,5-dichlorois known for its potential health hazards, as exposure can cause irritation to the skin, eyes, and respiratory system. Therefore, it is crucial to handle and use 2,4-Pentanedione, 1,5-dichlorowith caution and in accordance with proper safety protocols.

Uses

Used in Chemical Research and Manufacturing:
2,4-Pentanedione, 1,5-dichlorois used as a reagent in chemical research and manufacturing processes. Its unique properties and reactivity make it a valuable component in the synthesis of various organic compounds, contributing to the development of new materials and products in the chemical industry.

Upstream product

• 108-05-4 vinyl acetate 
• 79-04-9 chloroacetyl chloride 
• 123-54-6 acetylacetone 

Downstream Products

• 103729-39-1 yashabushidiol B (1,7-diphenylheptane-(3R)-(5R)-diol) 
• 86117-01-3 (4R,6R)-(+)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one 
• 109905-51-3 (2S,4S)-1,2:4,5-dianhydro-3-deoxypentitol 
• 129212-21-1 (3S,5S)-3,5-heptanediol 
• 135943-90-7 (2S,4R)-4,5-epoxy-1-phenyl-2-pentanol 
• 135943-93-0 (5S,7S)-8-phenyl-1-octene-5,7-diol 
• 135943-81-6 (+)-(4S,6R)-8-phenyloct-1-ene-4,6-diol 
• 135943-91-8 (2S,4S)-1-phenyl-2,4-nonanediol 
• 135943-94-1 (3R,5R)-1-phenyl-3,5-decanediol 
• 135943-80-5 (3R,5R)-3-benzoyl-5,6-epoxy-1-phenylhexanol 
• 135943-95-2 (2R,4R)-1-cyano-6-phenyl-2,4-bis(trimethylsiloxy)hexane 
• 135943-79-2 (3S,5R)-5,6-epoxy-1-phenyl-3-hexanol 
• 135943-79-2 (αR,2S)-α-(2-phenylethyl)oxirane-2-ethanol 
• 135943-83-8 (2S,4S)-1,5-diphenyl-2,4-pentanediol 

Relevant articles and documents

Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores

Genetically encoded macrocyclic peptide libraries with unnatural pharmacophores are valuable sources for the discovery of ligands for many targets of interest. Traditionally, generation of such libraries employs "early stage"incorporation of unnatural building blocks into the chemically or translationally produced macrocycles. Here, we describe a divergent late-stage approach to such libraries starting from readily available starting material: genetically encoded libraries of peptides. A diketone linchpin 1,5-dichloropentane-2,4-dione converts peptide libraries displayed on phage to 1,3-diketone bearing macrocyclic peptides (DKMP): shelf-stable precursors for Knorr pyrazole synthesis. Ligation of diverse hydrazine derivatives onto DKMP libraries displayed on phage that carries silent DNA-barcodes yields macrocyclic libraries in which the amino acid sequence and the pharmacophore are encoded by DNA. Selection of this library against carbonic anhydrase enriched macrocycles with benzenesulfonamide pharmacophore and nanomolar Kd. The methodology described in this manuscript can graft diverse pharmacophores into many existing genetically encoded phage libraries and significantly increase the value of such libraries in molecular discoveries.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

Optically Pure 1,3-Diols from (2R,4R)- and (2S,4S)-1,2:4,5-Diepoxypentane

Optically pure (>97percent ee) (2R,4R)-1,2:4,5-diepoxypentane (1) and its enantiomer can be prepared in three steps from 2,4-pentanedione without the need for chromatographic purification.Diepoxide 1 is an efficient precursor to a wide variety of opticall