13064-21-6Relevant articles and documents
Preparation of 4-arylcyclopentenes by sequential diallylation of arylaldehydes and ring-closing metathesis
Durand, Anne-Catherine,Brahmi, Lamia,Lahrech, Mokhtar,Hacini, Salih,Santelli, Maurice
, p. 1825 - 1833 (2005)
Allylsilane diallylation of aryl aldehydes followed by ring closure metathesis leads to 4-arylcyclopentenes in good yields. Copyright Taylor & Francis, Inc.
FeCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis
Ma, Lina,Li, Wenjuan,Xi, Hui,Bai, Xiaohui,Ma, Enlu,Yan, Xiaoyu,Li, Zhiping
, p. 10410 - 10413 (2016/08/24)
Exploiting catalytic carbonyl–olefin metathesis is an ongoing challenge in organic synthesis. Reported herein is an FeCl3-catalyzed ring-closing carbonyl–olefin metathesis. The protocol allows access to a range of carbo-/heterocyclic alkenes wi
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors
Aubele, Danielle L.,Truong, Anh P.,Dressen, Darren B.,Probst, Gary D.,Bowers, Simeon,Mattson, Matthew N.,Semko, Chris M.,Sun, Minghua,Garofalo, Albert W.,Konradi, Andrei W.,Sham, Hing L.,Zmolek, Wes,Wong, Karina,Goldbach, Erich,Quinn, Kevin P.,Sauer, John-Michael,Brigham, Elizabeth F.,Wallace, William,Nguyen, Lan,Bova, Michael P.,Hemphill, Susanna S.,Basi, Guriqbal
scheme or table, p. 5791 - 5794 (2011/10/19)
The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate β-amyloid peptide synthesis via γ-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by γ-secretase, are highlighted.