33558-75-7

Basic information

• Product Name: ALLYL(CHLOROMETHYL)DIMETHYLSILANE
• Synonyms: 3-CHLOROMETHYLDIMETHYLSILYL-1-PROPENE;ALLYL(CHLOROMETHYL)DIMETHYLSILANE;Silane, (chloromethyl)dimethyl-2-propen-1-yl-;chloromethyl-dimethyl-prop-2-enylsilane
• CAS NO: 33558-75-7
• Molecular Formula: C₆H₁₃ClSi
• Molecular Weight: 148.71
• Product Categories: Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Vinylsilanes, Allylsilanes
• Mol File: 33558-75-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 63-66 °C50 mm Hg(lit.)
• Flash Point: 82 °F
• Appearance: /
• Density: 0.907 g/mL at 25 °C(lit.)
• Vapor Pressure: 7.3mmHg at 25°C
• Refractive Index: n20/D 1.449(lit.)
• CAS DataBase Reference: ALLYL(CHLOROMETHYL)DIMETHYLSILANE(CAS DataBase Reference)
• NIST Chemistry Reference: ALLYL(CHLOROMETHYL)DIMETHYLSILANE(33558-75-7)
• EPA Substance Registry System: ALLYL(CHLOROMETHYL)DIMETHYLSILANE(33558-75-7)

Safety Data

• Hazard Codes: Xi
• Statements: 10
• Safety Statements: 16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 33558-75-7(Hazardous Substances Data)

Usage

Description

ALLYL(CHLOROMETHYL)DIMETHYLSILANE is an organosilicon compound that serves as a versatile intermediate in the synthesis of various organic compounds, including α-silyl alcohols, ethers, and amines. Its unique structure allows for a wide range of applications in different industries.

Uses

Used in Chemical Synthesis:
ALLYL(CHLOROMETHYL)DIMETHYLSILANE is used as a synthetic intermediate for the preparation of α-silyl alcohols, ethers, and amines. Its reactivity and stability make it a valuable compound in the chemical industry for creating a variety of organic molecules with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ALLYL(CHLOROMETHYL)DIMETHYLSILANE is used as a key building block for the development of new drugs and therapeutic agents. Its ability to form α-silyl alcohols, ethers, and amines allows for the creation of novel molecular structures with potential medicinal properties.
Used in Material Science:
In the field of material science, ALLYL(CHLOROMETHYL)DIMETHYLSILANE is utilized as a precursor for the synthesis of advanced materials with unique properties. These materials can be used in various applications, such as coatings, adhesives, and sealants, due to their enhanced performance characteristics.
Used in Electronics Industry:
The electronics industry also benefits from the use of ALLYL(CHLOROMETHYL)DIMETHYLSILANE as it can be employed in the development of new materials with improved electrical and thermal properties. These materials can be used in the manufacturing of electronic components, such as semiconductors and insulators, to enhance their performance and reliability.

InChI:InChI=1/C6H13ClSi/c1-4-5-8(2,3)6-7/h4H,1,5-6H2,2-3H3

Upstream product

• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 2622-05-1 allylmagnesium bromide 
• 106-95-6 allyl bromide 
• 1730-25-2 allylmagnesium bromide 
• 107-05-1 3-chloroprop-1-ene 

Downstream Products

• 18442-84-7 (Allyl-dimethyl-silylmethyl)-phenyl-phosphinsaeure-ethylester 
• 118722-59-1 2,2-dimethyl-1-<1-<(S)-2-(methoxymethyl)pyrrolidinyl>>-2-sila-4-pentene 
• 1833-51-8 chloromethyldimethylphenylsilane 
• 109790-06-9 (but-3-en-1-yl)dimethyl(phenyl)silane 
• 18163-14-9 3,3-dimethyl-1-thia-3-silacyclopentane 
• 36213-35-1 methyl 3-(dibutylphosphinyl)propionate 
• 88962-96-3 4-(di-n-butylphosphinyl)-4-phenylbutan-2-one 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 97695-82-4 1-phenyl-3,3,5-trimethyl-1-aza-3-silacyclopentane 
• 54322-72-4 (1-chlorobut-3-en-1-yl)benzene 
• 13064-21-6 hepta-1,6-dien-4-ylbenzene 
• 439296-86-3 allyl(2-phenylaminoethyl)dimethylsilane 
• 1745-18-2 1-allyl-4-chlorobenzene 

Relevant articles and documents

Cyclizations of 2-(Allyldimethylsilyl)ethyl Radicals

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Conformational analysis of 3,3-dimethyl-3-silathiane, 2,3,3-trimethyl-3- silathiane and 2-trimethylsilyl-3,3-dimethyl-3-silathiane-preferred conformers, barriers to ring inversion and substituent effects

The first conformational analysis of 3-silathiane and its C-substituted derivatives, namely, 3,3-dimethyl-3-silathiane 1, 2,3,3-trimethyl-3-silathiane 2, and 2-trimethylsilyl-3,3-dimethyl-3-silathiane 3 was performed by using dynamic NMR spectroscopy and B3LYP/6-311G(d,p) quantum chemical calculations. From coalescence temperatures, ring inversion barriers δG≠ for 1 and 2 were estimated to be 6.3 and 6.8 kcal/mol, respectively. These values are considerably lower than that of thiacyclohexane (9.4 kcal/mol) but slightly higher than the one of 1,1-dimethylsilacyclohexane (5.5 kcal/mol). The conformational free energy for the methyl group in 2 (-°G0 - 0.35 kcal/mol) derived from low-temperature13C NMR data is fairly consistent with the calculated value. For compound 2, theoretical calculations give δE value close to zero for the equilibrium between the 2-Me ax and 2-Meeq conformers. The calculated equatorial preference of the trimethylsilyl group in 3 is much more pronounced (-δG0 - 1.8 kcal/mol) and the predominance of the 3-SiMe 3 eq conformer at room temperature was confirmed by the simulated1H NMR and 2D NOESY spectra. The effect of the 2-substituent on the structural parameters of 2 and 3 is discussed. Copyright

N-derivatives of 1-deoxy nojirimycin

This invention relates to novel N-derivatives of 1-deoxy nojirimycin, to the method for their preparation and to their use in the treatment of diabetes and the use against retro-viruses, particularly in the treatment of acquired immuno-deficiency syndrome