131020-36-5 Usage
Description
1H-Benzimidazole-5-carboxylic acid, 1-methyl-, methyl ester (9CI), also known as Methyl 1-Methyl-1H-benzo[d]imidazole-5-carboxylate, is an organic compound with a molecular formula of C10H10N2O2. It belongs to the benzimidazole class of compounds, which are heterocyclic aromatic organic compounds containing two nitrogen atoms in a six-membered ring fused to a benzene ring. 1H-Benzimidazole-5-carboxylicacid,1-methyl-,methylester(9CI) is characterized by the presence of a carboxylic acid group at the 5-position, a methyl group at the 1-position, and a methyl ester group attached to the carboxylic acid. It is a white crystalline solid and is soluble in common organic solvents.
Uses
1H-Benzimidazole-5-carboxylic acid, 1-methyl-, methyl ester (9CI) is used as a reagent for the preparation of hydroxytryptamine receptor antagonists. Hydroxytryptamine, also known as serotonin, is a neurotransmitter that plays a crucial role in various physiological processes, including mood regulation, sleep, appetite, and pain perception. Antagonists of the hydroxytryptamine receptors can modulate these processes and have potential therapeutic applications in the treatment of various disorders, such as depression, anxiety, and migraine.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1H-Benzimidazole-5-carboxylic acid, 1-methyl-, methyl ester (9CI) is used as a key intermediate in the synthesis of hydroxytryptamine receptor antagonists. These antagonists can be developed into drugs for the treatment of various central nervous system disorders, such as depression, anxiety, and migraine. The benzimidazole core of this compound provides a versatile scaffold for the design and optimization of new drug candidates with improved potency, selectivity, and pharmacokinetic properties.
Additionally, the benzimidazole class of compounds has been extensively studied for their diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Therefore, 1H-Benzimidazole-5-carboxylic acid, 1-methyl-, methyl ester (9CI) may also find applications in other therapeutic areas, such as infectious diseases, inflammatory conditions, and cancer treatment, depending on the specific chemical modifications and the resulting biological activities of the synthesized compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 131020-36-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,0,2 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 131020-36:
(8*1)+(7*3)+(6*1)+(5*0)+(4*2)+(3*0)+(2*3)+(1*6)=55
55 % 10 = 5
So 131020-36-5 is a valid CAS Registry Number.
131020-36-5Relevant articles and documents
Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes
Dong, Yaxi,Breit, Bernhard
supporting information, p. 6765 - 6769 (2021/09/11)
CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.
PRMT5 INHIBITORS AND USES THEREOF
-
Paragraph 00452, (2014/07/08)
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described
COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV
-
Page/Page column 26, (2010/02/14)
The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.
