13206-67-2 Usage
General Description
1-(2-chloroethyl)-1-nitroso-3-phenylurea, also known as chloroethyl nitrosourea or Carmustine, is a chemical compound used in chemotherapy for the treatment of various types of cancer, including brain tumors, multiple myeloma, and Hodgkin's lymphoma. It belongs to the class of nitrosourea alkylating agents, which work by interfering with the DNA replication process in cancer cells, ultimately leading to their death. Carmustine is administered intravenously and is able to cross the blood-brain barrier, making it particularly effective in treating brain tumors. Common side effects of this compound include bone marrow suppression, nausea, and vomiting. It is considered a potent and potentially toxic drug and should be used under the supervision of a qualified healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 13206-67-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,0 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13206-67:
(7*1)+(6*3)+(5*2)+(4*0)+(3*6)+(2*6)+(1*7)=72
72 % 10 = 2
So 13206-67-2 is a valid CAS Registry Number.
13206-67-2Relevant articles and documents
The relationship between solvatochromic properties and in silico ADME parameters of new chloroethylnitrosourea derivatives with potential anticancer activity and their β-Cyclodextrin complexes
Fisli, Hassina,Hennig, Andreas,Chelaghmia, Mohamed Lyamine,Abdaoui, Mohamed
supporting information, (2021/02/27)
In view of the anticancer effect of nitrosoureas a set of four new N-(2-chloroethyl)-N-nitrosourea (CENU) derivatives was synthesized. An in silico absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) prediction study revealed that the
THE SYNTHESIS OF ANTINEOPLASTIC AGENTS. XXXII. N-NITROSOUREAS. I.
JOHNSTON,MCCALEB,MONTGOMERY
, p. 669 - 681 (2007/10/04)
-
