7144-13-0

Basic information

• Product Name: 1-(2-chloroethyl)-3-phenylurea
• Synonyms: urea, N-(2-chloroethyl)-N'-phenyl-
• CAS NO: 7144-13-0
• Molecular Formula: C₉H₁₁ClN₂O
• Molecular Weight: 198.6494
• Mol File: 7144-13-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 297.4°C at 760 mmHg
• Flash Point: 133.7°C
• Density: 1.247g/cm³
• Vapor Pressure: 0.00135mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-(2-chloroethyl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-phenylurea(7144-13-0)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-phenylurea(7144-13-0)

Safety Data

• Hazardous Substances Data: 7144-13-0(Hazardous Substances Data)

Usage

Description

1-(2-chloroethyl)-3-phenylurea, commonly known as chlorotoluron, is a chemical compound that functions as an herbicide. It is designed to control various types of grasses and broad-leaved weeds, exerting its effect by inhibiting the photosynthetic electron transport in plants, which ultimately results in the death of the targeted weeds. Due to its potential environmental and health risks, including being a possible endocrine disruptor and toxic to aquatic life, it is crucial to handle chlorotoluron with care and follow safety protocols.

Uses

Used in Agricultural Industry:
1-(2-chloroethyl)-3-phenylurea is used as a herbicidal agent for controlling grasses and broad-leaved weeds in agricultural settings. It is particularly effective when applied to crops such as cereals, potatoes, and sugar beets, where weed control is essential for optimal crop yield and quality. Additionally, it is utilized on non-crop land to prevent weed growth that could compete with desired vegetation or be a nuisance.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 62-53-3 aniline 
• 20729-41-3 acetaldehyde imine 
• 103-71-9 phenyl isocyanate 
• 13279-22-6 1-(phenylaminocarbonyl)aziridine 

Downstream Products

• 27151-01-5 4,5-dihydro-N-phenyl-2-oxazolamine 
• 1848-69-7 1-phenylimidazolidin-2-one 
• 5488-50-6 N-(2-iodo-ethyl)-N'-phenyl-urea 
• 27151-01-5 2-(phenylimino)oxazolidine 
• 226724-37-4 1-hexyl-3-phenyl-imidazolidin-2-one 
• 201470-78-2 3-octyl-1-phenylimidazolidin-2-one 
• 173901-19-4 4-(3-hexyl-2-imidazolidinon-1-yl)benzenesulfonyl chloride 
• 201470-20-4 4-(3-octyl-2-imidazolidinon-1-yl)benzenesulfonyl chloride 
• 959780-53-1 N-4-[125I]iodophenyl-N'-2-chloroethylurea 
• 146257-20-7 4-iodo-[3-(2-chloroethyl)ureido]benzene 
• 1311945-59-1 2-methoxyphenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1311945-60-4 2-ethoxyphenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1311945-61-5 2-chlorophenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1311945-62-6 2-fluorophenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonate 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells

The role and the importance of the sulfonate moiety in phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) were assessed using its bioisosteric sulfonamide equivalent leading to new cytochrome P450 1A1 (CYP1A1)-activated prodrugs designa

Design, synthesis, biological evaluation, and Structure - Activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4

Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs) and 13 of their tetrahydro-2-oxopyrimidin-1(2H)-yl analogues (PPB-SOs) were prepared and biologically evaluated. The antiproliferative activities of PIB-SOs on 16 cancer cell lines are