1943-83-5Relevant articles and documents
Synthetic method of nirudine hydrochloride
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Paragraph 0006; 0016; 0026-0028; 0033; 0035-0038; 0042-0044, (2021/08/25)
The invention belongs to the field of medicine synthesis and discloses a synthetic method of hydrochloride. The synthesis method provided by the invention takes 2 - chloroethylamine as a raw material and is subjected to amine ester exchange. After the condensation reaction and the nitrification reaction, bendamustine hydrochloride is obtained. To the synthesis method of the hydrochloride, the toxicity of the reaction reagent is reduced, the safety of the synthesis process is improved, and the accuracy of the reaction yield calculation is improved. The synthesis method provided by the invention is suitable for synthesis of hydrochloride, and the synthesized hydrochloride is used for preparing hydrochloride for injection.
Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation
DasGupta, Shirshendu,Murumkar, Prashant R.,Giridhar, Rajani,Yadav, Mange Ram
body text, p. 3604 - 3617 (2009/09/30)
Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the development of TACE inhibitors.
SYNTHESIS, STRUCTURE, AND ANTITUMOR ACTIVITY OF 5-SUBSTITUTED 5--2,2-DIMETHYL-1,3-DIOXANES
Kon'kov, S. A.,Kraiz, B. O.,Shenberg, N. N.,Gindin, V. A.,Stukov, A. N.,et al.
, p. 2092 - 2097 (2007/10/02)
5-Substituted 5--2,2-dimethyl-1,3-dioxanes were synthesized by the nitrosation of 5-substituted 5--2,2-dimethyl-1,3-dioxanes by sodium nitrite in 50percent aqueous acetic acid or by N2O3 in chloroform.Nitrosation takes place regioselectively, irrespective of the method.