13908-58-2

Basic information

• Product Name: N-(2-CHLOROETHYL)-N'-(3-PYRIDINYL)UREA
• Synonyms: N-(2-CHLOROETHYL)-N'-(3-PYRIDINYL)UREA;N-(2-Chloroethyl)-N'-pyridin-3-ylurea;1-(2-Chloroethyl)-1-(pyridin-3-yl)urea
• CAS NO: 13908-58-2
• Molecular Formula: C₈H₁₀ClN₃O
• Molecular Weight: 199.6375
• Mol File: 13908-58-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 143-144
• Boiling Point: 322.5 °C at 760 mmHg
• Flash Point: 148.9 °C
• Appearance: /
• Density: 1.309g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-CHLOROETHYL)-N'-(3-PYRIDINYL)UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROETHYL)-N'-(3-PYRIDINYL)UREA(13908-58-2)
• EPA Substance Registry System: N-(2-CHLOROETHYL)-N'-(3-PYRIDINYL)UREA(13908-58-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 13908-58-2(Hazardous Substances Data)

Usage

General Description

N-(2-chloroethyl)-N'-(3-pyridinyl)urea, also known as Timonacic, is a chemical compound with the molecular formula C8H10ClN3O. N-(2-CHLOROETHYL)-N'-(3-PYRIDINYL)UREA is a urea derivative with potential antineoplastic activity. It has been studied for its potential use in chemotherapy for various types of cancer, particularly for its ability to inhibit the growth of cancer cells. N-(2-chloroethyl)-N'-(3-pyridinyl)urea works by disrupting the replication and repair of DNA in cancer cells, thereby inhibiting their growth and promoting cell death. It is also being investigated for its potential use in combination with other chemotherapy drugs to improve cancer treatment outcomes.

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 1943-83-5 2-chloroethyl isothiocyanate 

Downstream Products

• 55661-37-5 1-(2-Chloroethyl)-1-nitroso-3-(3-pyridino)-urea 

Relevant articles and documents

Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: A novel class of potent and selective human enterovirus 71 inhibitors

When skeletons of Win compounds were used as templates, computer-assisted drug design led to the identification of a novel series of imidazolidinone derivatives with significant antiviral activity against enterovirus 71 (EV 71), the infection of which had

1, 3-DISUBSTITUTED IMIDAZOLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF CYP 17

The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R53, R54, p, q and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C17,20-lyase inhibitors.

Imidazolidinones as brain activators

This invention relates to imidazolidinone compounds of the formula STR1 wherein Q is methylene group or a single bond: R is a heterocyclic group selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and 1,3-thiazolyl which may be unsubstituted or with a substituent selected from the group consisting of lower alkyl, lower alkoxy and halogen atom, wherein R is bonded to Q or, when Q is a single bond, to the imidazolidinone ring, through the carbon atom of R; the ring A is an unsubstituted phenyl or a substituted phenyl having 1 or 2 substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen, lower alkylthio, trihalogeno-lower alkyl and nitro; Y is vinylene group or ethynylene; m is a integer from 1 to 6 and n is 0, 1 or 2, or a pharmacetically acceptable salt thereof. These compounds aer useful as cerebral activators, anti-depressants and nootropic drugs.