55661-37-5 Usage
Description
1-(2-chloroethyl)-1-nitroso-3-pyridin-3-ylurea is a chemical compound with the molecular formula C7H9ClN4O3, featuring a nitroso group and a pyridinylurea group. It is an organic compound that has demonstrated potential as an anticancer agent and a mutagen in genetic research, making it significant in the fields of medicinal and biological chemistry.
Uses
Used in Pharmaceutical Industry:
1-(2-chloroethyl)-1-nitroso-3-pyridin-3-ylurea is used as a potential anticancer agent for its ability to inhibit the growth of certain types of cancer cells. It functions by disrupting DNA synthesis and cell division, resulting in the suppression of tumor growth.
Used in Genetic Research:
In the field of genetic research, 1-(2-chloroethyl)-1-nitroso-3-pyridin-3-ylurea is used as a potential mutagen, contributing to the study of genetic mutations and their effects on cellular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 55661-37-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,6,6 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 55661-37:
(7*5)+(6*5)+(5*6)+(4*6)+(3*1)+(2*3)+(1*7)=135
135 % 10 = 5
So 55661-37-5 is a valid CAS Registry Number.
55661-37-5Relevant articles and documents
Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.
Crider,Lamey,Floss,Cassady,Bradner
, p. 848 - 851 (2007/10/02)
Nitrosourea derivatives 18-22 which utilize either a piperidine or pyridine ring as a carrier group were synthesized and evaluated for anticancer activity. N'-(1-Benzyl-4-piperidinyl)-N-(2-chloroethyl)-N-nitosourea hydrogen maleate (19) exhibited good activity against intracranial L1210 leukemia as well as the mouse ependymoblastoma brain tumor system. Compound 19 exhibited comparable activity in the Lewis lung carcinoma system to N,N'-bis(2-chloroethyl)-N-nitrosourea. Replacement of the N-benzyl group in both the 3-piperidinyl- and 4-piperidinylnitrosoureas resulted in less active compounds in all tumor systems tested. The 3-pyridylnitrosourea 22 was inactive in the L-1210 leukemia system.
