13307-60-3

Basic information

• Product Name: 2-Propanol, 2-methyl-1-(phenylthio)-
• CAS NO: 13307-60-3
• Molecular Formula: C10H14OS
• Molecular Weight: 182.287
• Mol File: 13307-60-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 2-methyl-1-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 2-methyl-1-(phenylthio)-(13307-60-3)
• EPA Substance Registry System: 2-Propanol, 2-methyl-1-(phenylthio)-(13307-60-3)

Safety Data

• Hazardous Substances Data: 13307-60-3(Hazardous Substances Data)

Upstream product

• 558-30-5 2-methyl-1,2-epoxypropane 
• 108-98-5 thiophenol 
• 64168-52-1 4'-nitrobenzenesulfenanilide 
• 75-05-8 acetonitrile 
• 115-11-7 isobutene 
• 75-91-2 tert.-butylhydroperoxide 
• 930-69-8 sodium thiophenolate 
• 7205-91-6 phenylthiomethyl chloride 
• 2388-10-5 lithium isopropoxide 
• 917-64-6 methyl magnesium iodide 
• 17277-58-6 methyl (phenylsulfanyl)acetate 

Downstream Products

• 27998-51-2 2-methyl-1-(phenylsulfonyl)propan-2-ol 
• 123065-78-1 methyl (E)-4-<2-(2,3-dihydro-3,3-dimethylbenzothien-5-yl)-1-propenyl>benzoate 
• 132102-36-4 <1-(2,3-dihydro-3,3-dimethylbenzothien-5-yl)ethyl>triphenylphosphonium bromide 
• 123065-77-0 (E)-4-[2-(2,3-dihydro-3,3-dimethylbenzo[b]thien-5-yl)-1-propenyl]benzoic acid 

Relevant articles and documents

Synthesis of β-Hydroxysulfides from Thiophenols and Disulfides with tert-Butyl Hydroperoxide as the Oxidant and Reactant

In this Communication, we developed a new procedure for the synthesis of β-hydroxysulfides from thiophenols or diaryl disulfides with TBHP as the oxidant. In the presence of zinc iodide or potassium iodide, with TBHP as the oxidant and pre-reactant, thiophenols and diaryl disulfides reacted with the methyl group of tBuOH smoothly and selectivity to give the corresponding 2-methyl-1-(arylthio)propan-2-ols as the terminal products in moderate to good yields.

Synthesis and in vitro evaluation of side chain-unsaturated analogs of 24a,24b-dihomo-1,25-dihydroxycholecalciferol

A synthesis and an in vitro evaluation of side chain-unsaturated analogs 3 and 4 of 24a, 24b-dihomo-1,25-dihydroxycholecalciferol (1) are described. Novel C(23a,24)-vitamin D synthons (sulfone 10 and aldehyde 11) were used for the synthesis of analog 4 and for the efficient preparation of the parent compound 1. The synthetic approach developed allows the use of easily available side chain fragments, such as oxirane 12 or Wittig reagent 15 for the preparation of compound 1 and analog 4, respectively. Introduction of a 24aE double bond results in a selective, 1000-fold increase in the binding affinity of analog 4 for the vitamin D receptor, compared to the affinity of 1, whereas the affinity of 4 for the vitamin D-binding protein and the activity in stimulating the differentiation of human promyelocytic leukemia HL-60 cells remained largely unchanged.

Boron Trifluoride-Promoted Reaction of Benzenesulphenanilides with Alkenes in Acetonitrile and Benzonitrile: Amidino- and Amido-sulphenylation of Alkenes

Benzenesulphenanilides (1) react at room temperature with alkenes in acetonitrile or benzonitrile in the presence of boron trifluoride-diethyl ether to give amidino sulphides (5; R=Me, Ph) in fair to good yields together with varying amounts of amido sulphides (7; R=Me, Ph) and arylamino sulphides (4), whereas at 100 deg C and in the presence of water 4'-nitrobenzenesulphenanilide affords amido sulphides (7; R=Me, Ph) as the main products.With cyclohexene a high selectivity for trans-addition is observed.With terminal alkenes the terminal sulphides are produced with high regioselectivity.The findings are consistent with a mechanism involving intermediacy of episulphonium ions (3) which result from alkene attack at the sulphur atom of an anilide-BF3 complex.