133095-91-7

Basic information

• Product Name: 3,4,5-TRIMETHOXYPHENYLMAGNESIUM BROMIDE SOLUTION 0.5M IN TETRAHYDROFURAN
• Synonyms: 3,4,5-TRIMETHOXYPHENYLMAGNESIUM BROMIDE SOLUTION 0.5M IN TETRAHYDROFURAN;3,4,5-Trimethoxyphenylmagnesium bromide solution;3,4,5-Trimethoxyphenylmagnesium bromide solution 0.5 in THF;3,4,5-Trimethoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal;3,4,5-TriMethoxyphenylMagnesiuM broMide, 0.25 M in THF;3,4,5-TriMethoxyphenylMagnesiuM broMide, 0.5M solution in THF, JKSeal;3,4,5-TriMethoxyphenylMagnesiuM broMide, 0.5 M solution in THF, SpcSeal;3,4,5-Trimethoxyphenylmagnesium bromide solution 0.5 M in THF
• CAS NO: 133095-91-7
• Molecular Formula: C₉H₁₁BrMgO₃
• Molecular Weight: 271.39084
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents
• Mol File: 133095-91-7.mol
• Article Data: 4

Chemical Properties

• Flash Point: <-20℃
• Appearance: /
• Density: 0.979 g/mL at 25 °C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4,5-TRIMETHOXYPHENYLMAGNESIUM BROMIDE SOLUTION 0.5M IN TETRAHYDROFURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXYPHENYLMAGNESIUM BROMIDE SOLUTION 0.5M IN TETRAHYDROFURAN(133095-91-7)
• EPA Substance Registry System: 3,4,5-TRIMETHOXYPHENYLMAGNESIUM BROMIDE SOLUTION 0.5M IN TETRAHYDROFURAN(133095-91-7)

Safety Data

• Hazard Codes: F+,C,F
• Statements: 12-14-19-34-37-40-11
• Safety Statements: 16-26-29-33-36/37/39-45
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• RTECS: LU5950000
• Hazardous Substances Data: 133095-91-7(Hazardous Substances Data)

Usage

Uses

(3,4,5-Trimethoxyphenyl)magnesium Bromide is useful as a reactant in the synthesis of several compounds with therapeutic potential.

InChI:InChI=1/C9H11O3.BrH.Mg/c1-10-7-5-4-6-8(11-2)9(7)12-3;;/h5-6H,1-3H3;1H;/q;;+1/p-1/rC9H11BrMgO3/c1-12-7-4-6(11-10)5-8(13-2)9(7)14-3/h4-5H,1-3H3

Upstream product

• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 7439-95-4 magnesium 

Downstream Products

• 133095-99-5 (2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(2,3,4-trimethoxy-phenyl)-tetrahydro-furan 
• 116781-15-8 (-)-L 659989 
• 121702-60-1 L 662418 
• 261158-28-5 (1R,2S,3R,4R)-6,7-methylenedioxy-2-(N-oxazolidinoyl)carbonyl-3-triisopropylsilyloxymethyl-1-(3',4',5'-trimethoxy)phenyl-4-(2''-trimethylsilylethoxy)methoxy-1,2,3,4-tetrahydronaphthalene 
• 757962-00-8 (4-methoxy-3-nitro-phenyl)-(3,4,5-trimethoxy-phenyl)-methanol 
• 1016544-73-2 (2-fluoro-4-(thiazol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanol 

Relevant articles and documents

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.

Identification of CKD-516: A potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors

Tubulin polymerization inhibitors had emerged as one of promising anticancer therapeutics because of their dual mechanism of action, i.e. apoptosis by cell-cycle arrest and VDA, vascular disrupting agent. VDAs are believed to be more efficient, less toxic