133174-25-1

Basic information

• Product Name: 5-Benzofuranol, 2,3-dihydro-2-(2-phenylethyl)-
• CAS NO: 133174-25-1
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Mol File: 133174-25-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Benzofuranol, 2,3-dihydro-2-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzofuranol, 2,3-dihydro-2-(2-phenylethyl)-(133174-25-1)
• EPA Substance Registry System: 5-Benzofuranol, 2,3-dihydro-2-(2-phenylethyl)-(133174-25-1)

Safety Data

• Hazardous Substances Data: 133174-25-1(Hazardous Substances Data)

Upstream product

• 138854-08-7 2,3-dihydro-5-methoxy-2-(2-phenylethyl)benzofuran 
• 13391-28-1 5-methoxybenzofuran 
• 122-78-1 phenylacetaldehyde 
• 139201-45-9 5-methoxy-2-(2-phenylethyl)benzofuran 
• 139201-44-8 2-(1-hydroxy-2-phenylethyl)-5-methoxybenzofuran 

Downstream Products

• 139201-60-8 2,3-dihydro-6-<4-(methylthio)benzyl>-2-(2-phenylethyl)-5-benzofuranol 
• 138854-29-2 7,8-dihydro-2-phenyl-7-(2-phenylethyl)-4-(2-phenoxyethyl)-4H-furo<2,3-g>-1,3,2-benzodioxaborin 
• 145275-25-8 7,8-dihydro-2-phenyl-2-(phenylethyl)-4H-furo<2,3-g>-1,3,2-benzodioxaborin 
• 139242-71-0 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenethyl)-5-benzofuranyl β-D-glucopyranosiduronic acid 
• 139201-68-6 methyl <2-(2-phenylethyl)-6-(3-phenoxypropyl)-2,3-dihydrobenzofuran-5-yl tri-O-acetyl-β-D-glucopyranosid>uronate 
• 138854-21-4 5-(benzyloxy)-6-<3-<(3-carbomethoxy-2-methyoxyquinolin-7-yl)thio>propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 138854-20-3 5-(benzyloxy)-2,3-dihydro-2-(2-phenylethyl)-6-<3-<4-(1H-tetrazol-5-yl)phenoxy>propyl>benzofuran 
• 138854-35-0 5-(benzyloxy)-6-<3-(4-carbomethoxyphenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 139201-52-8 2-<<3-<2,3-dihydro-5-(benzyloxy)-2-(2-phenylethyl)benzofuran-6-yl>propyl>thio>benzothiazole 
• 139201-54-0 6-<3-<(3-carboxy-2-methoxyquinolin-7-yl)thio>propyl>-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 138854-22-5 6-<3-<(3-carbomethoxy-2-methoxyquinolin-7-yl)thio>propyl>-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 138854-19-0 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 139201-53-9 6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 138853-91-5 2,3-dihydro-2-(2-phenylethyl)-6-<3-<4-(1H-tetrazol-5-yl)phenoxy>propyl>-5-benzofuranol 

Relevant articles and documents

Development of 2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a Potent and Orally Active Inhibitor of 5-Lipoxygenase

Leukotrienes are potent biological mediators of allergic and antiinflammatory diseases and are derived from arachidonic acid through the action of the 5-lipoxygenase.In this study, the syntheses and comparative biological activities of three series of 2,3-dihydro-2,6-disubstituted-5-benzofuranols with various substituents on position 3 are described.Compounds from each series were evaluated for their ability to inhibit the production of leukotriene B4 (LTB4) in human peripheral blood polymorphonuclear (PMN) leukocytes and the 5-lipoxygenase reaction in cell-free preparations from rat PMN leukocytes.The structure-activity relationships of each series in vitro and in vivo are presented.The bioavailability, metabolism, and toxicity profile of each series are discussed.The series with no substituent at position 3 was the most potent and among the compounds in that series 2,3-dihydro-6-(3-phenoxypropyl)2-(2-phenylethyl)-5-benzofuranol (46, L-670,630) was chosen for further development.