13391-28-1

Basic information

• Product Name: 5-Methoxybenzofuran
• Synonyms: 5-METHOXYBENZOFURAN;5-methoxy-benzofura;Benzofuran, 5-methoxy-;5-methoxy-1-benzofuran;5-Methoxybenzo[b]furan
• CAS NO: 13391-28-1
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.16
• Mol File: 13391-28-1.mol
• Article Data: 31

Chemical Properties

• Melting Point: 31 °C
• Boiling Point: 123 °C
• Flash Point: 99.13 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 0.181mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Methoxybenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxybenzofuran(13391-28-1)
• EPA Substance Registry System: 5-Methoxybenzofuran(13391-28-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 13391-28-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 19, p. 257, 1989 DOI: 10.1080/00397918908050977

InChI:InChI=1/C9H8O2/c1-10-8-2-3-9-7(6-8)4-5-11-9/h2-6H,1H3

Upstream product

• 39581-55-0 5-methoxy-benzofuran-3-one 
• 10242-08-7 5-methoxybenzofuran-2-carboxylic acid 
• 69034-13-5 p-methoxyphenoxyacetaldehyde diethyl acetal 
• 111437-45-7 2-<2-hydroxy-1-(isopropylthio)ethyl>-4-methoxyphenol 
• 197314-79-7 Methyl 3-(2-allyloxy-5-methoxyphenyl)propenoate 
• 150-76-5 4-methoxy-phenol 
• 13391-35-0 allyl (4-methoxyphenyl) ether 
• 584-82-7 2-allyl-4-methoxyphenol 
• 865759-99-5 2-allyl-1-(2-chloroethoxy)-4-methoxybenzene 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 93198-67-5 methyl (E)-3-(2-hydroxy-5-methoxyphenyl)acrylate 
• 68426-08-4 1-(2,2-dimethoxyethoxy)-4-methoxybenzene 
• 935-50-2 4,4-dimethoxycyclohexa-2,5-dienone 
• 13196-10-6 benzofuran-5-ol 

Downstream Products

• 139201-44-8 2-(1-hydroxy-2-phenylethyl)-5-methoxybenzofuran 
• 77440-98-3 chloro-6 methoxy-5 benzofuranne 
• 77440-95-0 chloro-2 methoxy-5 benzofuranne 
• 77440-97-2 chloro-4 methoxy-5 benzofuranne 
• 77440-96-1 chloro-3 methoxy-5 benzofuranne 
• 13391-32-7 2-ethyl-4-methoxy-phenol 
• 13196-10-6 benzofuran-5-ol 
• 58546-89-7 1-benzofuran-5-amine 
• 139201-45-9 5-methoxy-2-(2-phenylethyl)benzofuran 
• 133174-25-1 2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 138854-08-7 2,3-dihydro-5-methoxy-2-(2-phenylethyl)benzofuran 
• 138854-09-8 5-(allyloxy)-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 138853-84-6 6-allyl-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 138853-85-7 4-allyl-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 

Relevant articles and documents

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Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.

Method suitable for large-scale production of B-RAF kinase dimer inhibitor

The invention relates to a method for large-scale production of a B-RAF kinase dimer inhibitor 1-((1S, 1aS, 6bS)-5-((7-oxo-5, 6, 7, 8-tetrahydro-1, 8-diazanaphthalene-4-yl) oxy)-1a, 6b-dihydro-1H-cyclopropyl [b] benzofuran-1-yl)-3-(2, 4, 5- trifluorophenyl) urea (hereinafter sometimes referred to as a compound 1). The method enables impurities or by-products to be controlled to 0.05% or less without the use of expensive column chromatography operations. Thus, the method greatly reduces cost and is suitable for large-scale production.