39581-55-0

Basic information

• Product Name: 5-METHOXY-BENZOFURAN-3-ONE
• Synonyms: 5-METHOXY-BENZOFURAN-3-ONE;AKOS BC-0911;5-Methoxy-3(2H)-benzofuranone;5-Nitro-3-Benzofuranone (2);5-Methoxy-1-benzofuran-3(2H)-one;3(2H)-Benzofuranone, 5-Methoxy-
• CAS NO: 39581-55-0
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.15802
• Mol File: 39581-55-0.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 299.4°Cat760mmHg
• Flash Point: 125.7°C
• Appearance: /
• Density: 1.262g/cm³
• Vapor Pressure: 0.0012mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-METHOXY-BENZOFURAN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-BENZOFURAN-3-ONE(39581-55-0)
• EPA Substance Registry System: 5-METHOXY-BENZOFURAN-3-ONE(39581-55-0)

Safety Data

• Hazardous Substances Data: 39581-55-0(Hazardous Substances Data)

Usage

General Description

5-Methoxy-benzofuran-3-one is a chemical compound with the molecular formula C9H8O3. It is also known as isobenzofuran and has a molecular weight of 152.16 g/mol. 5-METHOXY-BENZOFURAN-3-ONE is a derivative of benzofuran, and it belongs to the class of organic compounds known as benzofurans. It is commonly used in the synthesis of pharmaceuticals and as a building block in organic chemistry. 5-METHOXY-BENZOFURAN-3-ONE has potential uses in medicinal chemistry for the development of new drugs and has also been studied for its pharmacological properties. Additionally, it has been investigated for its potential role in drug design and development. Overall, 5-Methoxy-benzofuran-3-one is a versatile chemical compound with various potential applications in the field of pharmaceuticals and organic chemistry.

InChI:InChI=1/C9H8O3/c1-11-6-2-3-9-7(4-6)8(10)5-12-9/h2-4H,5H2,1H3

Upstream product

• 75717-53-2 2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 17918-14-8 2,5-dimethoxybenzoyl chloride 
• 150-76-5 4-methoxy-phenol 
• 60770-20-9 2-(carboxymethoxy)-5-methoxybenzoic acid 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 60770-33-4 5-methoxybenzofuran-3-yl acetate 
• 107-14-2 chloroacetonitrile 
• 203524-87-2 1-(2-hydroxy-5-methoxyphenyl)-2-bromoethanone 
• 150-78-7 1,4-dimethoxybezene 
• 1204-22-4 2-chloro-1-(2,5-dimethoxy-phenyl)-ethanone 
• 2905-82-0 methyl 5-methoxy-2-hydroxybenzoate 
• 2612-02-4 5-methoxysalicylic acid 
• 104796-21-6 methyl 5-methoxy-2-(2-methoxy-2-oxoethoxy)benzoate 

Downstream Products

• 13391-28-1 5-methoxybenzofuran 
• 118610-60-9 methyl 2-(5-methoxybenzofuran-3-yl)acetate 
• 38216-55-6 5-methoxy-3-oxo-2-phenylmethylidene-2,3-dihydrobenzo[b]furan 
• 229323-38-0 2-benzyl-5-methoxy-3-oxo-2,3-dihydrobenzo[b]furan 
• 440633-62-5 2-(3-fluorobenzyl)-5-methoxy-3-oxo-2,3-dihydrobenzo[b]furan 
• 440633-64-7 2-(3-chlorobenzyl)-5-methoxy-3-oxo-2,3-dihydrobenzo[b]furan 
• 440633-69-2 5-methoxy-3-oxo-2-(3-phenylprop-1-yl)-2,3-dihydrobenzo[b]furan 
• 440633-59-0 5-methoxy-2-(2-methoxybenzyl)-3-oxo-2,3-dihydrobenzo[b]furan 
• 440633-60-3 5-methoxy-2-(3-methoxybenzyl)-3-oxo-2,3-dihydrobenzo[b]furan 
• 440633-61-4 5-methoxy-2-(4-methoxybenzyl)-3-oxo-2,3-dihydrobenzo[b]furan 
• 440633-67-0 2-cyclohexylmethyl-5-methoxy-3-oxo-2,3-dihydrobenzo[b]furan 

Relevant articles and documents

Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping approach to identify a series of novel polycyclic heterocyclic derivatives based on Evo as the topoisomerase I (Top1) inhibitor for the treatment of triple-negative breast cancer (TNBC), which is an aggressive subtype of breast cancer with limited treatment options. The most potent compound 7f inhibited cell growth in a human breast carcinoma cell line (MDA-MB-231) with an IC50 value of 0.36 μM. Further studies revealed that Top1 was the target of 7f, which directly induced irreversible Top1-DNA covalent complex formation or induced an oxidative DNA lesion through an indirect mechanism mediated by reactive oxygen species. More importantly, in vivo studies showed that 7f exhibited potent antitumor activity in a TNBC-patient-derived tumor xenograft model. These results suggest that compound 7f deserves further investigation as a promising candidate for the treatment of TNBC.

Microwave-Assisted Synthesis of Benzofuran-3(2H)-ones

A new method for the synthesis of benzofuran-3(2H)-ones under microwave conditions was developed. The reaction conditions were screened, and the scope of benzoate substrates was investigated. The results showed that our method could provide rapid access to these important dihydrobenzofuranones in 43% to 58% yields.

Novel evodiamine derivatives as well as preparation method and application of novel evodiamine derivatives

The invention relates to the field of medicinal chemistry and particularly relates to novel evodiamine derivatives and also discloses a preparation method of the novel evodiamine derivatives and an application of the novel evodiamine derivatives to treatm