133600-91-6

Basic information

• Product Name: [4-(3-Benzoyl-thiazolidin-2-yl)-2-methoxy-phenoxy]-acetic acid ethyl ester
• CAS NO: 133600-91-6
• Molecular Weight: 401.483
• Mol File: 133600-91-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(3-Benzoyl-thiazolidin-2-yl)-2-methoxy-phenoxy]-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(3-Benzoyl-thiazolidin-2-yl)-2-methoxy-phenoxy]-acetic acid ethyl ester(133600-91-6)
• EPA Substance Registry System: [4-(3-Benzoyl-thiazolidin-2-yl)-2-methoxy-phenoxy]-acetic acid ethyl ester(133600-91-6)

Safety Data

• Hazardous Substances Data: 133600-91-6(Hazardous Substances Data)

Upstream product

• 98896-96-9 2-(4-hydroxy-3-methoxyphenyl)thiazolidine 
• 121-33-5 vanillin 
• 98-88-4 benzoyl chloride 
• 105-36-2 ethyl bromoacetate 
• 133600-76-7 3-benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine 

Relevant articles and documents

Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists

A series of 3-benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were synthesized, and evaluated for their thromboxane A2 (TXA2) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α- (epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). A simple 2-arylthiazolidine derivative, 3- benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine (5a), showed mild TXA2 receptor antagonist activity. Modification of 5a led to 2-chloro-4-[3-(4- chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyaretic acid (29d), which showed 10 times more potent TXA2 receptor antagonist activity than 5a.