13362-56-6Relevant articles and documents
An environmentally friendly, cost effective synthesis of quinoxalines: The influence of microwave reaction conditions
Jeena, Vineet,Robinson, Ross S.
, p. 642 - 645 (2014)
A convenient, environmentally friendly and novel synthesis of quinoxalines using silica gel as the catalyst is described. The choice of microwave conditions has been shown to have a substantial impact on the reaction outcome with closed-vessel microwave irradiation resulting in the formation of quinoxalines in high yields and short reaction times. Preliminary mechanistic investigations have indicated that a slight build-up in pressure has a major impact on the reaction outcome.
An environmentally benign attribute for the expeditious synthesis of quinoxaline and its derivatives
Bhargava, Sangeeta,Soni,Rathore, Deepti
, (2019)
A simple, efficient, and environmentally friendly ionic liquid mediated protocol for the synthesis of quinoxaline derivatives using carbonyl substrate and phenylenediamines has been described. A range of ionic liquids were synthesized, characterized via IR, 1H and 13C NMR and used as a solvent as well as catalyst for above protocol. The catalytic activities of ILs were evaluated and the relationship between the catalytic activity and acidity was discussed. It was also found that among the all ILs, [Bmim]CF3SO3 was the most effective, eco-friendly and less expensive solvent and catalyst for the above etiquette. This method is of significant value due to the eco-friendly nature of ionic liquid and non usage of separate catalyst to drive the reaction forward. The protocol proves to be efficient and environmentally benign in terms of good to excellent yields, low reaction times, simple work-up, ease of recovery, and reusability of ionic liquid for six times.
Ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br): A green and neutral reaction media for the efficient, catalyst-free synthesis of quinoxaline derivatives
Zare, Abdolkarim,Hasaninejad, Alireza,Parhami, Abolfath,Moosavi-Zare, Ahmad Reza,Khedri, Fatemeh,Parsaee, Zahra,Abdolalipoor-Saretoli, Maasoomeh,Khedri, Maasoomeh,Roshankar, Mehrnoosh,Deisi, Hanafieh
, p. 1315 - 1324 (2010)
Quinoxaline derivatives were produced in excellent yields and short reaction times via the condensation of 1,2-diamines with 1,2-diketones in the neutral ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br) under catalyst-free and microwave irradia
Silica sulfuric acid (SSA)/polyethylene glycol (PEG) as a recyclable system for the synthesis of quinoxalines and pyrazines
Huang, Tieqiang,Jiang, Danna,Chen, Jiuxi,Gao, Wenxia,Ding, Jinchang,Wu, Huayue
, p. 3334 - 3343 (2011)
An efficient and facile method has been developed for the condensation of 1,2-diamines with-hydroxyketones in polyethylene glycol (PEG) to quinoxalines and pyrazines with good yields in the presence of silica sulfuric acid (SSA). The important features of the methodology are simple operations, environmentally friendliness, and no requirement for metal catalysts. Additionally, the catalyst system (SSA/PEG) could be recovered easily and reused.
NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy
Wang, Yan-Bing,Shi, Linlin,Zhang, Xiaojie,Fu, Lian-Rong,Hu, Weinan,Zhang, Wenjing,Zhu, Xinju,Hao, Xin-Qi,Song, Mao-Ping
, p. 947 - 958 (2021/01/14)
A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.
Application of a reusable Co-based nanocatalyst in alcohol dehydrogenative coupling strategy: Synthesis of quinoxaline and imine scaffolds
Panja, Dibyajyoti,Paul, Bhaskar,Balasubramaniam, Bhuvaneshwari,Gupta, Raju K.,Kundu, Sabuj
, (2020/01/21)
A nitrogen doped carbon supported cobalt catalyzed efficient synthesis of imines and quinoxaline motifs is reported. Co(OAc)2-Phen/Carbon-800 (Co-phen/C-800) showed the superior reactivity compared to other materials prepared at different temperature, in the synthesis of quinoxalines by the coupling between diamines and diols. Moreover, applying the transfer hydrogenation and acceptorless dehydrogenative coupling strategy, imines and quinoxaline derivatives were synthesized from the nitro compounds. The practical applicability of this protocol was demonstrated by the gram-scale synthesis and the reusability of the catalyst upto 8th cycle. Furthermore, several kinetic experiments were carried out to realize the probable mechanism.
