133721-88-7

Basic information

• Product Name: Benzeneacetonitrile, 2-fluoro-a-hydroxy-
• CAS NO: 133721-88-7
• Molecular Formula: C8H6FNO
• Molecular Weight: 151.14
• Mol File: 133721-88-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 2-fluoro-a-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 2-fluoro-a-hydroxy-(133721-88-7)
• EPA Substance Registry System: Benzeneacetonitrile, 2-fluoro-a-hydroxy-(133721-88-7)

Safety Data

• Hazardous Substances Data: 133721-88-7(Hazardous Substances Data)

Upstream product

• 151-50-8 potassium cyanide 
• 446-52-6 2-Fluorobenzaldehyde 
• 82128-76-5 α-[(trimethylsilyl)oxy]-α-(o-fluorophenyl)acetonitrile 
• 773837-37-9 sodium cyanide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 485759-27-1 (S)-2-hydroxy-2-(2-fluorophenyl)acetonitrile 
• 290374-44-6 (R)-2-hydroxy-2-(2-fluorophenyl)acetonitrile 
• 126644-02-8 cyano(2-fluorophenyl)methyl acetate 
• 84145-28-8 (+/-)-2-amino-2'-fluorophenylacetic acid 
• 1584127-58-1 C₁₁H₁₁FO₄ 
• 192884-55-2 methyl 2-(2-fluorophenyl)-2-hydroxyacetate 
• 389-31-1 2-fluoromandelic acid 

Relevant articles and documents

Solid phase behavior in the chiral systems of various 2-hydroxy-2-phenylacetic acid (mandelic acid) derivatives

The solid phase behavior of a series of monosubstituted F-, Cl-, Br-, I-, and CH3- and two 2,4-halogen-disubstituted 2-hydroxy-2-phenylacetic acid (mandelic acid) derivatives was investigated. The study includes detailed information about melting temperature, melting enthalpy, X-ray diffraction data, as well as selected binary phase diagrams of the respective chiral systems. Aside from the known metastable conglomerate 2-chloromandelic acid, evidence for two more metastable conglomerates was found.

Relationships between the racemic structures of substituted mandelic acids containing 8- and 10-membered hydrogen bonded dimer rings

The structures of 27 monosubstituted mandelic acids, including several of their polymorphs, plus unsubstituted mandelic acid itself (two polymorphs) are investigated for structural similarity. The results, presented pictorially as a structural relationship plot, show that rather more structures are built up from the carboxyl-chain hydroxyl hydrogen bonded dimer than from the conventional carboxylic acid dimer. The results show how all the structures are related and, based on the two types of dimer, the degree of similarity that they possess. Some structures with Z′ > 1 contain both sorts of dimers and there are many examples of isostructural sets within the structures so far determined. We also present an example where analysing similarity in related families of structures highlights a structure that should be present and which has indeed then proceeded to be synthesised and determined.

Enzymatic kinetic resolution of racemic cyanohydrins via enantioselective acylation

Enzymatic kinetic resolution of a series of aromatic and aliphatic cyanohydrins in organic media has been investigated. The behavior of potential lipases, molecular sieves, acyl reagent, reaction temperature, and organic solvents on the kinetic resolution was studied. The influence of substrate structure, steric, and electronic nature and position of the aryl substituent on the enantioselectivity was discussed. Under the optimized reaction conditions, good enantioselectivity could be achieved for most of the investigated compounds. Specifically, substrates 1a, 1c, 1d, 1f, 1u could be resolved with the kinetic enantiomer ratio (E) higher than 200.