192884-55-2

Basic information

• Product Name: Benzeneacetic acid, 2-fluoro-a-hydroxy-, methyl ester
• CAS NO: 192884-55-2
• Molecular Formula: C9H9FO3
• Molecular Weight: 184.167
• Mol File: 192884-55-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-fluoro-a-hydroxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-fluoro-a-hydroxy-, methyl ester(192884-55-2)
• EPA Substance Registry System: Benzeneacetic acid, 2-fluoro-a-hydroxy-, methyl ester(192884-55-2)

Safety Data

• Hazardous Substances Data: 192884-55-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 389-31-1 2-fluoromandelic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 133721-88-7 (+/-)-2-hydroxy-2-(2-fluorophenyl)acetonitrile 
• 132115-73-2 methyl 2-fluoro-α-oxo-benzeneacetate 

Downstream Products

• 1584127-58-1 C₁₁H₁₁FO₄ 
• 703-43-5 2-(2-fluorophenyl)-2-hydroxyacetamide 
• 1314081-70-3 (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-phenylacetate 
• 181040-24-4 methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate 
• 135660-93-4 α-bromo-o-fluorobenzoic acid methyl ester 

Relevant articles and documents

Kinetic Resolution of Allylic Alcohol with Chiral BINOL-Based Alkoxides: A Combination of Experimental and Theoretical Studies

The development and characterization of enantioselective catalytic kinetic resolution of allylic alcohols through asymmetric isomerization with chiral BINOL derivatives-based alkoxides as bifunctional Br?nsted base catalysts were described in the study. A number of chiral BINOL derivatives-based alkoxides were synthesized, and their structure-enantioselectivity correlation study in asymmetric isomerization identified a promising chiral Br?nsted base catalyst, which afforded various chiral secondary allylic alcohols (ee up to 99%, S factor up to >200). In the mechanistic study, alkoxide species were identified as active species and the phenol group of BINOL largely affected the high reactivity and enantioselectivity via hydrogen bonding between the chiral Br?nsted base catalyst and substrates. The strategy is the first successful synthesis strategy of various chiral secondary allylic alcohols through enantioselective transition-metal-free base-catalyzed isomerization. The applicability of the strategy had been demonstrated by the synthesis of the bioactive natural product (+)-veraguensin.

Kinetic resolution of mandelate esters via stereoselective acylation catalyzed by lipase PS-30

By using lipase PS-30 as catalyst, the kinetic resolution of a series of racemic mandelate esters has been achieved via stereoselective acylation. The value of kinetic enantiomeric ratio (E) reached up to 197.5. Substituent effect is briefly discussed.

Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof

2-Iminooxyphenylacetic acid derivatives STR1 where the substituents and the index have the following meanings: R1 is C(CO2 CH3)=NOCH3 (Ia), C(CONHCH3)=NOCH3 (Ib), C(CONH2)=NOCHs