135660-93-4

Basic information

• Product Name: α-bromo-o-fluorobenzoic acid methyl ester
• Synonyms: α-bromo-o-fluorobenzoic acid methyl ester
• CAS NO: 135660-93-4
• Molecular Weight: 247.064
• Mol File: 135660-93-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α-bromo-o-fluorobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-bromo-o-fluorobenzoic acid methyl ester(135660-93-4)
• EPA Substance Registry System: α-bromo-o-fluorobenzoic acid methyl ester(135660-93-4)

Safety Data

• Hazardous Substances Data: 135660-93-4(Hazardous Substances Data)

Usage

General Description

α-bromo-o-fluorobenzoic acid methyl ester is a chemical compound with the molecular formula C8H6BrFO2. It is an ester derivative of o-fluorobenzoic acid and contains a bromine atom at the alpha position and a fluorine atom at the ortho position of the benzene ring. α-bromo-o-fluorobenzoic acid methyl ester is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various pharmaceutical compounds and advanced materials. It is known for its versatile reactivity and is used as a key intermediate in the synthesis of active pharmaceutical ingredients and agrochemicals. Its unique molecular structure and reactivity make it valuable in the development of new drugs and materials with potential applications in the pharmaceutical and agricultural industries.

Upstream product

• 57486-67-6 methyl o-fluorophenylacetate 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 389-31-1 2-fluoromandelic acid 
• 192884-55-2 methyl 2-(2-fluorophenyl)-2-hydroxyacetate 

Downstream Products

• 181040-24-4 methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate 
• 1218019-39-6 (2-fluoro-phenyl)-phenylamino-acetic acid methyl ester 
• 444892-79-9 4-[(2-fluoro-phenyl)-methoxycarbonyl-methyl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST

Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as A2A receptor antagonist.

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives

The fifth paper in this series describes the culmination of our investigations into the development of a potent and selective ETA receptor antagonist for the treatment of diseases mediated by ET-1. Receptor site mapping of several ETA antagonists prepared previously identified a common cationic binding site which prompted synthesis of phenoxyphenylacetic acid derivative 13a, which showed good in vitro activity (IC50 59 nM, rat aortic ET(A)). Optimization of 13a led to the identification of 27b, which exhibited an IC50 of 4 nM. Although this did not translate into the expected in vivo potency, a compound of comparable in vitro activity, 27a (RPR118031A), showed a far better pharmacokinetic profile and in vivo potency (75 μmol/kg) and was duly proposed and accepted as a development candidate.

Antimuscarinic bronchodilators

Compounds having the formula: wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CR3, C1-C4 alkyl, C1-C4 alkoxy and hydroxy, or