1342235-24-8

Basic information

• Product Name: (Z)-6-(3-(dimethylamino)-2-(4-fluorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• Synonyms: (Z)-6-(3-(dimethylamino)-2-(4-fluorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 1342235-24-8
• Molecular Weight: 340.354
• Mol File: 1342235-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-6-(3-(dimethylamino)-2-(4-fluorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-6-(3-(dimethylamino)-2-(4-fluorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(1342235-24-8)
• EPA Substance Registry System: (Z)-6-(3-(dimethylamino)-2-(4-fluorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(1342235-24-8)

Safety Data

• Hazardous Substances Data: 1342235-24-8(Hazardous Substances Data)

Upstream product

• 37682-31-8 ethyl o-nitrophenoxyacetate 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1342235-35-1 6-(4-(4-fluorophenyl)isoxazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 

Relevant articles and documents

Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4]oxazin- 3(4H)-one derivatives as a new class of anti-cancer agents

The synthesis of novel 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives has been carried out using trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reaction as a key step. This method does not require the use of environmentally harmful AlCl3 or moisture sensitive acid chloride. A number of compounds containing the benzooxazinone moiety attached to a five-membered central heterocyclic ring was synthesized and tested for their anti-cancer properties in vitro against three cell lines e.g. A549 (lung), DLD-1 (colorectal adenocarcinoma) and MV4-11 (acute myeloid leukemia). Some of them showed anti-cancer activities along with a number of reference compounds tested. Few of them showed promising anti-leukemic properties. A brief Structure-Activity-Relationship study within the series is presented. An imidazole derivative 9c containing benzene ring with a para-CF3 group at C-2 position was identified as a potent anti-leukemic agent.