37682-31-8

Basic information

• Product Name: Acetic acid, (2-nitrophenoxy)-, ethyl ester
• CAS NO: 37682-31-8
• Molecular Formula: C10H11NO5
• Molecular Weight: 225.201
• Mol File: 37682-31-8.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Acetic acid, (2-nitrophenoxy)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, (2-nitrophenoxy)-, ethyl ester(37682-31-8)
• EPA Substance Registry System: Acetic acid, (2-nitrophenoxy)-, ethyl ester(37682-31-8)

Safety Data

• Hazardous Substances Data: 37682-31-8(Hazardous Substances Data)

Upstream product

• 824-39-5 sodium o-nitrophenate 
• 64-17-5 ethanol 
• 5735-53-5 1,4-benzoxazine 
• 105-39-5 chloroacetic acid ethyl ester 
• 88-75-5 2-hydroxynitrobenzene 
• 1878-87-1 2-nitrophenoxyacetic acid 
• 105-36-2 ethyl bromoacetate 
• 824-38-4 potassium 2-nitrophenoxide 
• 20142-87-4 2-(2-nitrophenoxy)acetyl chloride 

Downstream Products

• 27320-99-6 3,4-dihydro-7-chloro-3-oxo-2H-1,4-benzoxazine 
• 1878-87-1 2-nitrophenoxyacetic acid 
• 116977-28-7 2-(2-nitrophenoxy)acetohydroxamic acid 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 1263183-83-0 C₁₃H₁₀N₄O₄S 
• 1263183-97-6 C₉H₁₀N₄O₄S 
• 77729-22-7 (2-nitro-phenoxy)-acetic acid hydrazide 
• 1342235-17-9 6-(1-(3,5-dichlorophenyl)-4-phenyl-1H-pyrazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1086390-21-7 6-(2-(3-methylphenyl)acetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-24-8 (Z)-6-(3-(dimethylamino)-2-(4-fluorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-27-1 (Z)-6-(3-(dimethylamino)-2-(2-chlorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-28-2 (Z)-6-(3-(dimethylamino)-2-(3-chlorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-31-7 (Z)-6-(3-(dimethylamino)-2-(3-methylphenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-33-9 (Z)-6-(3-(dimethylamino)-2-(4-bromophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 

Relevant articles and documents

Design, synthesis and biological evaluation of oxime lacking Psammaplin inspired chemical libraries as anti-cancer agents

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro. Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro.

Deconstructive di-functionalization of unstrained, benzo cyclic amines by C-N bond cleavage using a recyclable tungsten catalyst

With H2WO4 as the catalyst and H2O2 as the oxidant, we herein report a deconstructive difunctionalization of the C-N bond in unstrained, benzo cyclic amines to generate an ester group and nitro group simultaneously. The preliminary mechanistic studies suggested that the corresponding hydroxamic acid is the key intermediate for this transformation. Importantly, with the utilization of this transformation, we achieved an interesting approach for the ring contraction of quinoline to indole, an example of scaffold hopping in a hetero-aromatic system.

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections

Two series of ω-phenoxy contained acylhydroxamic acids as novel urease inhibitors were designed and synthesized. Biological activity evaluations revealed that ω-phenoxypropinoylhydroxamic acids were more active than phenoxyacetohydroxamic acids. Out of these compounds, 3-(3,4-dichlorophenoxy)propionylhydroxamic acid c24 showed significant potency against urease in both cell free extract (IC50 = 0.061 ± 0.003 μM) and intact cell (IC50 = 0.89 ± 0.05 μM), being over 450- and 120-fold more potent than the clinically prescribed urease inhibitor AHA, repectively. Non-linear fitting of experimental data (V-[S]) suggested a mixed-type inhibition mechanism and a dual site binding mode of these compounds.