134395-20-3 Usage
Description
4-tert-ButyldiMethylsilyl-5'-chloro-6'-oxo SiMvastatin is an intermediate compound in the preparation of Simvastatin (S485000) derivatives. It is characterized by its light yellow film appearance.
Uses
Used in Pharmaceutical Industry:
4-tert-ButyldiMethylsilyl-5'-chloro-6'-oxo SiMvastatin is used as an intermediate in the synthesis of Simvastatin derivatives, which are important for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Research and Development:
4-tert-ButyldiMethylsilyl-5'-chloro-6'-oxo SiMvastatin is also utilized in research and development settings to study the chemical properties and potential applications of Simvastatin and its derivatives, contributing to the advancement of pharmaceutical science and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 134395-20-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,3,9 and 5 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 134395-20:
(8*1)+(7*3)+(6*4)+(5*3)+(4*9)+(3*5)+(2*2)+(1*0)=123
123 % 10 = 3
So 134395-20-3 is a valid CAS Registry Number.
134395-20-3Relevant articles and documents
Synthesis of L-669,262, a Potent HMG-CoA Reductase Inhibitor
Stokker, Gerald E.
, p. 5983 - 5986 (2007/10/02)
Synthesis of L-669,262, isosimvastatin-3-one, has been achieved in seven steps from simvastatin (MK-733) and has been shown to be one of the most potent inhibitors of HMG-CoA reductase found to date.The synthesis of the 6-methyl homolog of simvastatin is also described.
