135369-46-9

Basic information

• Product Name: 10-Benzyl-7,8-dihydro-2-methylthio-9H,10H-thiopyrano<3,2-d>-1,2,4-triazolo<1,5-a>pyrimidin-5-one
• CAS NO: 135369-46-9
• Molecular Weight: 344.461
• Mol File: 135369-46-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 10-Benzyl-7,8-dihydro-2-methylthio-9H,10H-thiopyrano<3,2-d>-1,2,4-triazolo<1,5-a>pyrimidin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 10-Benzyl-7,8-dihydro-2-methylthio-9H,10H-thiopyrano<3,2-d>-1,2,4-triazolo<1,5-a>pyrimidin-5-one(135369-46-9)
• EPA Substance Registry System: 10-Benzyl-7,8-dihydro-2-methylthio-9H,10H-thiopyrano<3,2-d>-1,2,4-triazolo<1,5-a>pyrimidin-5-one(135369-46-9)

Safety Data

• Hazardous Substances Data: 135369-46-9(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 132030-57-0 7,8-Dihydro-2-methylthio-9H,10H-thiopyrano<3,2-d>-1,2,4-triazolo<1,5-a>pyrimidin-5-one 
• 63449-37-6 ethyl 4-<(2-ethoxy-2-oxoethyl)sulfanyl>butanoate 
• 58509-73-2 ethyl 3-oxothiane-2-carboxylate 

Relevant articles and documents

On triazoles XLII [1,2]. A new convenient method for the N-alkylation of highly insoluble cyclic amides

A simple N-alkylation method of highly insoluble cyclic amides based on the high solubility of their easily isolable tetraalkylammonium and tetraalkylphosphonium salts was elaborated. The method has a rather wide scope, it is not influenced by the identity of the different rings attached to the 1,2,4-triazolo[1,5-a]-pyrimidinone moiety of isomers 1 and 2, nor the presence of the triazole substituents. It proceeds smoothly without any unwanted by-products, at relatively low temperatures, and is not sensitive to moisture. The method allows an easy isolation of all possible N-alkylated derivatives 3, 7, and 8. Spectral analysis of isomers 3, 7, and 8 showed that our previous results concerning the formation of 3 type N-alkylated derivatives as main products of the N-alkylations as well as the tautomeric structure of the non-alkylated isomers 1 and 2 is correct. However, it also showed that the isolation of a single N-alkylated isomer 3 and its comparison with the corresponding non-alkylated derivative to prove its tautomeric structure may lead to mistakes.