135481-57-1

Basic information

• Product Name: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE
• Synonyms: 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;6-benzyl-1H,2H,3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-2,4-dione;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-2,4(1H,3H)-dione;6-Benzyl-5,6,7,8-tetrahyd...;5,6,7,8-Tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;NSC 525977;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H);6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE
• CAS NO: 135481-57-1
• Molecular Formula: C₁₄H₁₅N₃O₂
• Molecular Weight: 257.29
• Mol File: 135481-57-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.33
• Refractive Index: 1.652
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.04±0.20(Predicted)
• CAS DataBase Reference: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE(135481-57-1)
• EPA Substance Registry System: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE(135481-57-1)

Safety Data

• Hazardous Substances Data: 135481-57-1(Hazardous Substances Data)

Usage

General Description

6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione is a chemical compound that falls under the category of tetrahydro-1H-Pyrido[4,3-d]pyrimidines. It has a complex molecular structure with benzyl groups. Its molecular formula is C14H14N2O2. While it is part of various chemical databases, specific details including its properties, uses, or involvement in any chemical reactions or biological processes, are not readily available or extensively researched in scientific literature. It's important to handle all chemicals with the appropriate safety measures.

InChI:InChI=1/C14H15N3O2/c18-13-11-9-17(8-10-4-2-1-3-5-10)7-6-12(11)15-14(19)16-13/h1-5H,6-9H2,(H2,15,16,18,19)

Upstream product

• 135481-54-8 4-ethoxy-5,6,7,8-tetrahydro-6-(phenylmethyl)-pyrido<4,3-d>pyrimidin-2(1H)-one 
• 57-13-6 urea 
• 159660-85-2 1-benzyl-4-aminotetrahydropyridine-3-carboxylic acid methyl ester 
• 67140-12-9 6-benzyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-pyrido<4,3-d>pyrimidin-4-one 
• 111-94-4 3,3'-Iminodipropionitrile 
• 782-87-6 N-benzylbis(2-cyanoethyl)amine 
• 100-39-0 benzyl bromide 
• 14247-04-2 4-amino-1-benzyl-1.2.5.6-tetrahydropyridine-3-carbonitrile 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Downstream Products

• 778574-06-4 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine 
• 635698-66-7 6-Benzyl-2,4-dibromo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 
• 1207358-07-3 C₂₅H₃₄N₆O₄ 
• 1207358-19-7 C₂₄H₂₈N₈O₂ 
• 1208901-69-2 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride 
• 1207358-03-9 C₂₀H₂₆N₆O₂ 
• 1207358-49-3 C₂₆H₃₆N₆O₄ 
• 1207358-51-7 C₂₁H₂₈N₆O₂ 
• 1542711-17-0 N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate 
• 1542711-20-5 C₂₈H₃₁N₅O₂ 
• 1542704-38-0 N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 1233932-38-1 6-benzyl-2-chloro-5,6,7,8-tetrahydropyrido [4,3-d]pyrimidine 
• 1609485-37-1 6-Benzyl-2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 
• 1609485-39-3 (4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening

Rapid Overlay of Chemical Structures (ROCS), which can rapidly identify potentially active compounds by shape comparison, is recognized as a powerful virtual screening tool. By ROCS, a class of novel Hsp90 inhibitors was identified. The calculated binding mode of the most potent hit 36 guided us to design and synthesize a series of analogs (57a-57h). Over 100-fold improvement was achieved in the target-based assay. The most potent compound 57h inhibited Hsp90 with IC50 0.10 ± 0.01 μM. It also showed much improved cell potency and ligand efficiency. Our study showed that ROCS is efficient in the identification of novel cores of Hsp90 inhibitors. 57h can be ideal leads for further optimization.