13626-59-0

Basic information

• Product Name: 3-METHOXY-ISOXAZOLE-5-CARBOXYLIC ACID
• Synonyms: 3-METHOXY-ISOXAZOLE-5-CARBOXYLIC ACID;5-Isoxazolecarboxylic acid, 3-Methoxy-
• CAS NO: 13626-59-0
• Molecular Formula: C₅H₅NO₄
• Molecular Weight: 143.1
• Product Categories: Heterocycles series;Building Blocks;Carboxy;Isoxazole
• Mol File: 13626-59-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 348.6 °C at 760 mmHg
• Flash Point: 164.6 °C
• Appearance: /
• Density: 1.403 g/cm³
• Vapor Pressure: 1.87E-05mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHOXY-ISOXAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-ISOXAZOLE-5-CARBOXYLIC ACID(13626-59-0)
• EPA Substance Registry System: 3-METHOXY-ISOXAZOLE-5-CARBOXYLIC ACID(13626-59-0)

Safety Data

• Hazardous Substances Data: 13626-59-0(Hazardous Substances Data)

Usage

Uses

3-Methoxyisoxazole-5-carboxylic acid

InChI:InChI=1/C5H5NO4/c1-9-4-2-3(5(7)8)10-6-4/h2H,1H3,(H,7,8)

Upstream product

• 67-56-1 methanol 
• 6567-35-7 3-bromo-5-isoxazolecarboxylic acid 
• 20724-56-5 3-chloro-5-isoxazolecarboxylic acid 
• 16880-11-8 3-methoxyisoxazole-5-carboxylic acid methyl ester 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 10068-07-2 methyl 3-hydroxy-5-isoxazolecarboxylate 

Downstream Products

• 16880-11-8 3-methoxyisoxazole-5-carboxylic acid methyl ester 
• 54258-24-1 3-methoxy-5-isoxazolecarboxylic acid chloride 
• 35166-36-0 3-methoxy-5-hydroxymethylisoxazole 
• 2763-94-2 5-aminomethyl-3-methoxyisoxazole 
• 54258-27-4 3-Methoxy-5-(1-hydroxyiminoaethyl)isoxazol 
• 54258-29-6 3-Methoxy-5-propionylisoxazol 
• 54258-31-0 3-Methoxy-5-(1-aminopropyl)isoxazol 
• 935888-70-3 C₂₅H₃₂N₄O₉ 
• 1217794-37-0 C₂₄H₂₁ClF₂N₆O₅ 
• 1217794-38-1 C₂₃H₂₀ClF₂N₇O₅ 
• 1217794-39-2 C₂₃H₂₁ClF₂N₈O₄ 
• 1217794-40-5 C₂₂H₂₀ClF₂N₉O₄ 
• 1217794-41-6 C₂₃H₂₂ClF₂N₉O₄ 
• 916922-05-9 C₁₁H₁₅NO₄S 

Relevant articles and documents

Structure-activity studies of 6-substituted decahydroisoquinoline-3- carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity

We have explored the excitatory amino acid antagonist activity in a series of decahydroisoquinoline-3-carboxyic acids, and within this series found the potent and selective AMPA antagonist (3SR,4aRS,6RS,8aRS)-6-(2-(1H-tetrazol- 5-yl)ethyl)decahydroisoquin

NEW BIARYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

Practical synthesis of a potent bradykinin B1 antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide

(Chemical Equation Presented) A practical and efficient synthesis of bradykinin B1 antagonist 1 is described. A convergent strategy was utilized which involved synthesis of three fragments: 3, 6, and 7. Cross coupling of fragments 6 and 7 followed by amidation with 3 enabled efficient synthesis of 1 in 19 steps total, a 35% overall yield from commercially available pyridine 10. The key to the success of the synthesis was the development of a fluorodenitration step to install the fluorine in pyridine 7 and a catalytic enantioselective hydrogenation of N-acyl enamide 9 to set the stereochemistry.