16880-11-8

Basic information

• Product Name: 5-Isoxazolecarboxylicacid,3-methoxy-,methylester(8CI,9CI)
• Synonyms: 5-Isoxazolecarboxylicacid,3-methoxy-,methylester(8CI,9CI);5-Isoxazolecarboxylic acid, 3-Methoxy-, Methyl ester;Methyl 3-Methoxyisoxazole-5-carboxylate;3-Methoxy-isoxazole-5-carboxylic acid methyl ester
• CAS NO: 16880-11-8
• Molecular Formula: C₆H₇NO₄
• Molecular Weight: 157.12
• Product Categories: OXAZOLE
• Mol File: 16880-11-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Isoxazolecarboxylicacid,3-methoxy-,methylester(8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Isoxazolecarboxylicacid,3-methoxy-,methylester(8CI,9CI)(16880-11-8)
• EPA Substance Registry System: 5-Isoxazolecarboxylicacid,3-methoxy-,methylester(8CI,9CI)(16880-11-8)

Safety Data

• Hazardous Substances Data: 16880-11-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 13626-59-0 3-methoxyisoxazole-5-carboxylic acid 
• 10068-07-2 methyl 3-hydroxy-5-isoxazolecarboxylate 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 205115-22-6 3-benzyloxyisoxazole-5-carboxylic acid methyl ester 
• 205115-33-9 2-Benzyl-3-oxo-2,3-dihydro-isoxazole-5-carboxylic acid methyl ester 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 35166-36-0 3-methoxy-5-hydroxymethylisoxazole 
• 145441-09-4 3-Methoxy-isoxazole-5-carboxylic acid (2,6-dimethyl-phenyl)-amide 
• 13626-59-0 3-methoxyisoxazole-5-carboxylic acid 
• 143268-25-1 2-<(3-methoxy-5-isoxazolyl)methyl>-3-imino-6-phenyl-2,3-dihydropyridazine hydrochloride 
• 143268-27-3 2-<(3-methoxy-5-isoxazolyl)methyl>-3-imino-6-(p-chlorophenyl)-2,3-dihydropyridazine hydrochloride 
• 143268-28-4 2-<(3-methoxy-5-isoxazolyl)methyl>-3-imino-8-phenyl-2,3-dihydrobenzopyridazine hydrochloride 
• 100241-86-9 3-methoxy-5-(N-methyl-N-benzylaminoethyl)isoxazole 
• 2763-94-2 5-aminomethyl-3-methoxyisoxazole 

Relevant articles and documents

THAILANSTATIN ANALOGS

The invention provides novel cytotoxic compounds and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this invention relates to novel thailanstatin A analogs, useful as cytotoxic small molecule toxins i

O-Alkylation of 3-hydroxyisoxazoles predominates under Mitsunobu conditions

Regiochemical control in the functionalization of ambident nucleophiles is of particular interest in organic chemistry. Herein, we demonstrate that O-alkylation of ambident 3-hydroxyisoxazoles, which are heterocyclic bioisosteres of carboxylic acids, predominates under Mitsunobu conditions. In several cases, excellent O-regioselectivity (≥95%) was observed. It is noteworthy that reactions were complete within 15 min at room temperature. Furthermore, the conditions are compatible with a range of alcohols that cover all of the typical protecting groups for the 3-hydroxyisoxazole motif, providing milder, simpler and less hazardous protocols to those commonly followed in the literature.

MALONONITRILE COMPOUND AS PESTICIDES

The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represent nitrogen or CR5, provided that 1 to 3 of X1, X2, X3 and X4 represent nitrogen, and Z represents oxygen, sulfur or NR6, which has pest-controlling activity.