1365267-37-3

Basic information

• Product Name: Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]-
• Synonyms: Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]-
• CAS NO: 1365267-37-3
• Molecular Formula: C₂₂H₂₁N₃O₇
• Molecular Weight: 439.41804
• Mol File: 1365267-37-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 803.8±65.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• PKA: 3.48±0.36(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]-(1365267-37-3)
• EPA Substance Registry System: Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]-(1365267-37-3)

Safety Data

• Hazardous Substances Data: 1365267-37-3(Hazardous Substances Data)

Usage

Description

Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]is a complex organic compound with a unique chemical structure. It is characterized by its benzoic acid core, with a series of functional groups and amorpholinylphenyl moiety attached to it. Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]is known for its role as an intermediate in the synthesis of pharmaceuticals, specifically in the production of Rivaroxaban, a novel antithrombotic agent.

Uses

1. Used in Pharmaceutical Synthesis:
Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]is used as an intermediate in the synthesis of Bis-[Des(5-Chloro-2-carboxythienyl)] Rivaroxaban Phthalamide (B415135), which is an impurity of Rivaroxaban (R538000). Rivaroxaban is a highly potent and selective, direct FXa inhibitor, making it an essential compound in the development of antithrombotic medications.
2. Used in Antithrombotic Applications:
In the pharmaceutical industry, Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]contributes to the development of antithrombotic agents, such as Rivaroxaban. These agents are crucial in the prevention and treatment of blood clot-related conditions, including deep vein thrombosis, pulmonary embolism, and stroke.
3. Used in Research and Development:
Benzoic acid, 2-[[[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]aMino]carbonyl]also plays a significant role in research and development within the pharmaceutical sector. It is utilized in the study of the chemical properties and interactions of various compounds, as well as in the development of new drugs and therapies targeting blood clotting disorders and related conditions.

Upstream product

• 446292-08-6 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 1365267-36-2 N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]benzene-1,2-diamide 

Relevant articles and documents

PROCESS FOR DETERMINING THE SUITABILITY FOR DISTRIBUTION OF A BATCH OF A THIOPHENE-2-CARBOXAMIDE DERIVATIVE

The present invention relates to a process for determining the suitability for distribution of a batch of rivaroxaban or of a pharmaceutical composition thereof. In particular, it also relates to two impurities of rivaroxaban, to their use as reference markers to determine the purity of a sample of rivaroxaban or a composition thereof, to analytical methods for determining the purity of a sample of rivaroxaban or a composition thereof and to a process of preparing rivaroxaban or pharmaceutical compositions thereof which are free or substantially free of such impurities.