136582-33-7

Basic information

• Product Name: N-(2-bromobenzyl)-2-iodobenzamide
• Synonyms: N-(2-bromobenzyl)-2-iodobenzamide
• CAS NO: 136582-33-7
• Molecular Weight: 416.056
• Mol File: 136582-33-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-bromobenzyl)-2-iodobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromobenzyl)-2-iodobenzamide(136582-33-7)
• EPA Substance Registry System: N-(2-bromobenzyl)-2-iodobenzamide(136582-33-7)

Safety Data

• Hazardous Substances Data: 136582-33-7(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 3959-05-5 2-bromobenzylamine 

Downstream Products

• 742699-04-3 N-(2-bromobenzyl)-N-ethynyl-2-iodobenzamide 
• 632330-08-6 2-(2-bromobenzyl)-3-methylidene-2,3-dihydro-1H-isoindol-1-one 
• 742699-02-1 N-(2-bromobenzyl)-2-iodo-N-((trimethylsilyl)ethynyl)benzamide 
• 19793-96-5 (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one 

Relevant articles and documents

Synthesis of 3-(arylmethylene)isoindolin-1-ones from ynamides by Heck-Suzuki-Miyaura domino reactions. Application to the synthesis of lennoxamine

Substituted 3-(arylmethylene)isoindolin-1-ones can be efficiently synthesized from various ynamides and boronic acids by palladium-catalyzed Heck-Suzuki-Miyaura domino reactions. This methodology has been applied to the total synthesis of lennoxamine and a concise route to this isoindolobenzazepine alkaloid was achieved in eight steps from 2,3-dimethoxybenzoic acid via a key intermediate ynamide.

Heck - Suzuki - Miyaura domino reactions involving ynamides. An efficient access to 3-(arylmethylene)isoindolinones

(Matrix Presented) Substituted 3-(arylmethylene)isoindolin-1-ones can be efficiently synthesized in a stereoselective manner from various ynamides and boronic acids by palladium-catalyzed Heck-Suzuki-Miyaura domino reactions.