19793-96-5

Basic information

• Product Name: (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one
• Synonyms: (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one
• CAS NO: 19793-96-5
• Molecular Weight: 311.383
• Mol File: 19793-96-5.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one(19793-96-5)
• EPA Substance Registry System: (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one(19793-96-5)

Safety Data

• Hazardous Substances Data: 19793-96-5(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 73178-23-1 N-benzyl-2-iodobenzamide 
• 100-46-9 benzylamine 
• 293744-55-5 N-benzyl-2-(2'-phenylethynyl)benzamide 
• 7506-50-5 N-(o-chlorobenzoyl)benzylamine 
• 536-74-3 phenylacetylene 
• 609-67-6 2-Iodobenzoyl chloride 
• 136582-33-7 N-(2-bromobenzyl)-2-iodobenzamide 
• 3959-05-5 2-bromobenzylamine 
• 100-39-0 benzyl bromide 
• 40523-32-8 3-(phenylmethylene)isoindol-1-one 
• 583-55-1 1-Bromo-2-iodobenzene 
• 201230-82-2 carbon monoxide 
• 615-42-9 1,2-Diiodobenzene 

Downstream Products

• 104563-13-5 2,3-Dibenzyl-3-(4-hydroxy-phenyl)-2,3-dihydro-isoindol-1-one 
• 39142-92-2 N,9-dibenzyl-8-azabicyclo<4.3.0>nona-1(6),2,4-trien-7-one 

Relevant articles and documents

N-benzyl-3-benzylideneisoindolin-1-one

The title compound, C22H17NO, is formed by the palladium-catalyzed reaction between N-benzyl-o-iodotenzamide and phenylacetylene. The molecules contain three planar parts, namely the isoindolinone moiety (A) and the phenyl rings of t

Synthesis of 2-(1,2,3-Triazolyl)benzamide Derivatives by a Copper(I)-Catalyzed Multicomponent Reaction

The copper-catalyzed multicomponent reaction of 2-iodobenzamides, NaN3, and terminal alkynes for the synthesis of 2-(1,2,3-triazolyl)benzamide derivatives was achieved in a one-step process over a short period of time under mild conditions. The transformation involved a C(aryl)–N bond formation process followed by an azide–alkyne cycloadditon reaction. The absence of external base was crucial for the preferred reaction pathway to occur.

Synthesis of 3-substituted isoindolin-1-ones via a tandem desilylation, cross-coupling, hydroamidation sequence under aqueous phase-transfer conditions

A simple and expedient method for the synthesis of 3-methylene-isoindolin-1-ones 4 under aqueous phase-transfer conditions has been developed. Starting from 2-iodobenzamides 1 and (silyl)alkynes, the products are obtained in high yields and short reaction times (30 min) with the use of inexpensive CuCl/PPh3 catalyst system in the presence of n-Bu4NBr (TBAB) as a phase-transfer agent. Terminal alkynes are conveniently "unmasked" upon in situ desilylation under the reaction conditions. Alkynes possessing heterocyclic moieties were also found as amenable substrates. Furthermore, a one-pot process starting from 2-iodobenzamides 1, aryl halides (bromides or iodides) and trimethylsilylacetylene (TMSA) as a convenient acetylene surrogate was also shown to be feasible under Pd/Cu catalysis.