40523-32-8

Basic information

• Product Name: 1H-Isoindol-1-one, 2,3-dihydro-3-(phenylmethylene)-, (3Z)-
• CAS NO: 40523-32-8
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Mol File: 40523-32-8.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: 1H-Isoindol-1-one, 2,3-dihydro-3-(phenylmethylene)-, (3Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 2,3-dihydro-3-(phenylmethylene)-, (3Z)-(40523-32-8)
• EPA Substance Registry System: 1H-Isoindol-1-one, 2,3-dihydro-3-(phenylmethylene)-, (3Z)-(40523-32-8)

Safety Data

• Hazardous Substances Data: 40523-32-8(Hazardous Substances Data)

Upstream product

• 122889-67-2 2-Bromo-N-phenylacetyl-benzamide 
• 36081-66-0 2'-bromo-2-phenylacetophenone 
• 32183-76-9 2-(phenylethynyl)benzonitrile 
• 4767-56-0 (Z)-3-benzylidenephthalide 
• 77287-34-4 formamide 
• 20871-31-2 2,3-dihydro-3-hydroxy-3-(phenylmethyl)-1H-isoindol-1-one 
• 60901-21-5 o-styrylbenzoic acid 
• 3930-83-4 o-iodobenzamide 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 1084-95-3 2-(2'-phenylethynyl)benzoic acid 
• 33578-05-1 methyl 2-(phenylethynyl)benzoate 
• 14178-42-8 2-benzamidopyridine 1-oxide 
• 65-85-0 benzoic acid 
• 637-44-5 phenylpropyolic acid 

Downstream Products

• 40523-36-2 (Z)-3-benzylidene-2-methyl-2,3-dihydro-1H-isoindolin-1-one 
• 39142-91-1 3-benzyl-2,3-dihydro-1H-isoindolin-1-one 
• 19793-96-5 (Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one 

Relevant articles and documents

SET photochemistry of phthalimide anion and its reactivity with hydrogen donors

The investigation of the photochemistry of phthalimide anion has uncovered its exceptional reactivity with hydrogen donors such as alcohols, toluene, ethers and amines. Photoreactions can be conducted to high conversions and photoadducts are formed in high yield and with predictable regioselectivity. Exploratory studies have revealed that SET from the excited phthalimide anion to phthalimide is a thermodinamically favourable step that produces the electrophilic phthalimidyl radical and is the key step of the process.

Copper-mediated oxidative C-H/N-H activations with alkynes by removable hydrazides

The efficient copper-mediated oxidative C-H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N-2-pyridylhydrazide allowed for domino C-H/N-H functionalization. The approach featured remarkable functional group compatibility and ample substrate scope. Thereby, highly functionalized aromatic and heteroaromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C-H cleavage.

Preparation method of cis-3-alkoxy-1-methylene isoindole derivative

The invention relates to a preparation method of a cis-3-alkoxy-1-methylene isoindole derivative. The preparation method comprises the following step: synthesizing cis- 3-alkoxy-1-methylene isoindolewith high stereoselectivity by taking a p-alkyne phenyl imidoate compound as a raw material and organic or inorganic alkali as a catalyst. The method is low in catalytic cost, mild in reaction condition, relatively high in synthetic yield and simple to operate. By deriving 3-alkoxy-1-methylene isoindole, isoindolinone, 3-amino-1-methylene isoindole and 1-alkyl-3-methylene isoindole can be synthesized efficiently. The derivatives are core structural units of many natural products, exist in molecules of various natural products and medicines widely and have relatively wide biological activity. The invention provides a novel method for synthesizing 3-alkoxy-1-methylene isoindole and the derivatives.