1374568-30-5

Basic information

• Product Name: 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone
• Synonyms: 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone
• CAS NO: 1374568-30-5
• Molecular Weight: 462.023
• Mol File: 1374568-30-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone(1374568-30-5)
• EPA Substance Registry System: 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone(1374568-30-5)

Safety Data

• Hazardous Substances Data: 1374568-30-5(Hazardous Substances Data)

Upstream product

• 1374568-07-6 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 1374568-40-7 2-(3,4,5-trimethoxyphenyl)benzopyrazine 
• 150114-69-5 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde 

Relevant articles and documents

Oxidative homologation of aldehydes to α-ketoaldehydes by using iodoform, o-iodoxybenzoic acid, and dimethyl sulfoxide

An efficient three-step synthetic route to α-ketoaldehydes starting from aryl aldehydes is reported. The aldehydes were treated with iPrMgCl and iodoform to obtain β-diiodoalcohols, which were then oxidized with o-iodoxybenzoic acid at room temperature to the corresponding β-diiodoketones. Subsequent reaction of the β-diiodoketone to the α-ketoaldehyde occurred under oxygen transfer from dimethyl sulfoxide. These sensitive products were in situ cyclized with o-phenylenediamine to form the stable monosubstituted quinoxalines, which could be characterized and isolated easily. α-Ketoaldehydes are a versatile, highly reactive moiety for the synthesis of heterocyclic compounds. We investigated the transformation of aldehydes into α-ketoaldehydes via β-diiodoketone intermediates and finally applied the procedure to the synthesis of peptidic substrates. Copyright