1374568-40-7

Basic information

• Product Name: 2-(3,4,5-trimethoxyphenyl)benzopyrazine
• Synonyms: 2-(3,4,5-trimethoxyphenyl)benzopyrazine
• CAS NO: 1374568-40-7
• Molecular Weight: 296.326
• Mol File: 1374568-40-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,4,5-trimethoxyphenyl)benzopyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4,5-trimethoxyphenyl)benzopyrazine(1374568-40-7)
• EPA Substance Registry System: 2-(3,4,5-trimethoxyphenyl)benzopyrazine(1374568-40-7)

Safety Data

• Hazardous Substances Data: 1374568-40-7(Hazardous Substances Data)

Upstream product

• 51490-01-8 1-(3,4,5-trimethoxyphenyl)-2-bromoethanone 
• 95-54-5 1,2-diamino-benzene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 150114-69-5 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde 
• 1374568-30-5 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone 
• 1374568-07-6 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanol 

Relevant articles and documents

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues

Bacterial resistance to antimicrobial agents has become an increasingly serious health problem in recent years. Among the strategies by which resistance can be achieved, overexpression of efflux pumps such as NorA of Staphylococcus aureus leads to a sub-lethal concentration of the antibacterial agent at the active site that in turn may predispose the organism to the development of high-level target-based resistance. With an aim to improve both the chemical stability and potency of our previously reported 3-phenyl-1,4-benzothiazine NorA inhibitors, we replaced the benzothiazine core with different nuclei. None of the new synthesized compounds showed any appreciable intrinsic antibacterial activity, and, in particular, 2-(3,4-dimethoxyphenyl)quinoline (6 c) was able to decrease, in a concentration-dependent manner, the ciprofloxacin MIC against the norA-overexpressing strains S. aureus SA-K2378 (norA++) and SA-1199B (norA+/A116E GrlA).

Oxidative homologation of aldehydes to α-ketoaldehydes by using iodoform, o-iodoxybenzoic acid, and dimethyl sulfoxide

An efficient three-step synthetic route to α-ketoaldehydes starting from aryl aldehydes is reported. The aldehydes were treated with iPrMgCl and iodoform to obtain β-diiodoalcohols, which were then oxidized with o-iodoxybenzoic acid at room temperature to the corresponding β-diiodoketones. Subsequent reaction of the β-diiodoketone to the α-ketoaldehyde occurred under oxygen transfer from dimethyl sulfoxide. These sensitive products were in situ cyclized with o-phenylenediamine to form the stable monosubstituted quinoxalines, which could be characterized and isolated easily. α-Ketoaldehydes are a versatile, highly reactive moiety for the synthesis of heterocyclic compounds. We investigated the transformation of aldehydes into α-ketoaldehydes via β-diiodoketone intermediates and finally applied the procedure to the synthesis of peptidic substrates. Copyright