138333-10-5Relevant articles and documents
Potent matrix metalloproteinase inhibitors: Amino-carboxylate compounds containing modifications of the P1 residue
Xue, Chu-Biao,He, Xiaohua,Roderick, John,DeGrado, William F.,Decicco, Carl,Copeland, Robert A.
, p. 379 - 384 (2007/10/03)
A series of amino-carboxylate inhibitors of matrix metalloproteinases containing different P1 modifications have been synthesized. It was discovered that a toluenesulfonamide-type substituent at the P1 position considerably enhances the binding affinity of inhibitors for stromelysin. Replacements of the P2'-P3' residues with nonpeptide components result in loss of inhibitory activity.