138386-58-0

Basic information

• Product Name: 2-Propenoic acid, 3-[2-[(triphenylphosphoranylidene)amino]phenyl]-, methyl ester, (E)-
• CAS NO: 138386-58-0
• Molecular Formula: C28H24NO2P
• Molecular Weight: 437.478
• Mol File: 138386-58-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[2-[(triphenylphosphoranylidene)amino]phenyl]-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[2-[(triphenylphosphoranylidene)amino]phenyl]-, methyl ester, (E)-(138386-58-0)
• EPA Substance Registry System: 2-Propenoic acid, 3-[2-[(triphenylphosphoranylidene)amino]phenyl]-, methyl ester, (E)-(138386-58-0)

Safety Data

• Hazardous Substances Data: 138386-58-0(Hazardous Substances Data)

Upstream product

• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 603-35-0 triphenylphosphine 
• 612-41-9 2-nitrocinnamic acid 
• 39228-29-0 methyl 2-nitrocinnamate 
• 88939-75-7 methyl β-(o-aminophenyl)acrylate 

Downstream Products

• 839672-50-3 methyl 3-[2-((4-biphenyl)iminomethyleneamino)phenyl]acrylate 
• 928006-45-5 KYS₀₅₀₇₉ 
• 955009-86-6 3-biphenyl-4-yl-2-[(5-N,N-dibenzylaminopentyl)-N'-methylamino]-4-methoxycarbonylmethyl-3,4-dihydroquinazoline 
• 955011-81-1 KYS₀₅₀₈₉ 
• 1076689-75-2 2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline 
• 1076689-73-0 4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline 
• 138386-84-2 3-(4-Methoxy-phenyl)-9H-pyrido[2,3-b]indole-4-carboxylic acid methyl ester 
• 138386-83-1 3-Phenyl-9H-pyrido[2,3-b]indole-4-carboxylic acid methyl ester 
• 138386-80-8 2-p-Tolylamino-quinoline-3-carboxylic acid methyl ester 
• 115891-42-4 2-anilino-3-carbomethoxyquinoline 
• 139210-13-2 2-(4-Methoxy-phenylamino)-quinoline-3-carboxylic acid methyl ester 
• 174534-47-5 4-methoxycarbonylmethyl-2-(1-piperidinyl)-3-phenyl-3,4-dihydroquinazoline 

Relevant articles and documents

Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice

In the previous article we have reported that 3,4-dihydroquinazoline 1 is a potent and selective T-type calcium channel blocker that exhibited strong anti-cancer activity in vitro. Compound 1·2HCl was further in vivo evaluated against A549 xenograft in BALB/c nude mice, which exhibited 49% tumor-weight inhibition through intravenous administration of 2 mg/kg of body weight and was more potent than doxorubicin. Moreover, compound 1·2HCl has an oral bioavailability of 98% with LD50 values of 693 mg/kg (po route) and 40.0 mg/kg (iv route) of body weight. In addition, its efficient scale-up synthetic method was developed.

3,4-DIHYDROQUINAZOLINE DERIVATIVES

The present invention relates to 3,4-dihydroquinazoline derivatives, a process of preparing them and a pharmaceutical composition including them. The 3,4-dihydroquinazoline derivatives of the present invention have excellent T-type calcium channel blocking effect and anti-cancer activity.

2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses

The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.