138408-36-3

Basic information

• Product Name: 2-Propenoic acid, 3-[1-(triphenylmethyl)-1H-imidazol-4-yl]-, methyl ester, (E)-
• CAS NO: 138408-36-3
• Molecular Formula: C26H22N2O2
• Molecular Weight: 394.473
• Mol File: 138408-36-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[1-(triphenylmethyl)-1H-imidazol-4-yl]-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[1-(triphenylmethyl)-1H-imidazol-4-yl]-, methyl ester, (E)-(138408-36-3)
• EPA Substance Registry System: 2-Propenoic acid, 3-[1-(triphenylmethyl)-1H-imidazol-4-yl]-, methyl ester, (E)-(138408-36-3)

Safety Data

• Hazardous Substances Data: 138408-36-3(Hazardous Substances Data)

Upstream product

• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 3465-72-3 urocanic Acid 
• 3465-72-3 (E)-3-(1H-imidazol-4-yl)propenoic acid 
• 67-56-1 methanol 
• 76-83-5 trityl chloride 
• 70346-51-9 (E)-methyl 3-(1H-imidazol-4-yl)acrylate 
• 54260-89-8 trans-4-imidazoleacrylic acid methyl ester hydrochloride 

Downstream Products

• 112547-04-3 (E)-N-[3-(1-Triphenylmethyl-1H-imidazol-4-yl)allyl]phthalimid 
• 132553-79-8 3-(1-trityl-1H-imidazol-4-yl)prop-2-enamine 
• 138408-38-5 (E)-3-(1-Triphenylmethyl-1H-imidazol-4-yl)allylchlorid Hydrochlorid 
• 199007-42-6 2-Benzyl-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester 
• 199007-54-0 2-Benzyl-3-(1-trityl-1H-imidazol-4-yl)-propionic acid 
• 220378-41-6 1-(triphenylmethyl)-4-(2-carboxaldehydoethenyl)imidazole 
• 438206-59-8 (Z)-2-bromo-3-(1-trityl-1H-imidazol-4-yl)acrylic acid methyl ester 
• 438206-65-6 (E)-2-bromo-3-(1-trityl-1H-imidazol-4-yl)acrylic acid methyl ester 
• 220377-99-1 5-(1-trityl-1H-imidazol-4-yl)pentan-1-ol 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 102676-68-6 ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pentanoate 
• 102676-61-9 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde 
• 220377-96-8 ethyl (2E)-5-(1-triphenylmethyl-1H-imidazol-4-yl)pent-2-enoate 
• 52237-35-1 3-(1H-imidazol-5-yl)propan-1-ol monohydrobromide 

Relevant articles and documents

ISOQUINOLINES AS INHIBITORS OF HPK1

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Synthesis of 7-15N-oroidin and evaluation of utility for biosynthetic studies of pyrrole-imidazole alkaloids by microscale 1H-15N HSQC and FTMS

Numerous marine-derived pyrrole-imidazole alkaloids (PIAs), ostensibly derived from the simple precursor oroidin, 1a, have been reported and have garnered intense synthetic interest due to their complex structures and in some cases biological activity; however very little is known regarding their biosynthesis. We describe a concise synthesis of 7-15N-oroidin (Id) from urocanic acid and a direct method for measurement, of 15N incorporation by pulse labeling and analysis by 1D 1H-15N HSQC NMR and FTMS. Using a mock pulse labeling experiment, we estimate the limit of detection (LOD) for incorporation of newly biosynthesized PIA by 1D 1H-15N HSQC to be 0.96 μg equivalent of 15N-oroidin (2.4 nmole) in a background of 1500 μg of unlabeled oroidin. (about 1 part per 1600). 7-15N-Oroidin will find utility in biosynthetic feeding experiments with live sponges to provide direct information to clarify the pathways leading to more complex pyrrole-imidazole alkaloids.

New building blocks for fluorinated bioimidazole derivatives II: Preparation of β-fluorourocanic acids

Replacement of vinyl hydrogen with fluorine is based on addition of an FBr equivalent to a double bond followed by HBr elimination. This sequence has been adapted to prepare 3-fluoro-3-imidazolylpropenoic acids (β-fluorourocanic acids), and the related fl