54260-89-8

Basic information

• Product Name: methyl (E)-3-(1H-imidazol-4-yl)acrylate monohydrochloride
• Synonyms: methyl (E)-3-(1H-imidazol-4-yl)acrylate monohydrochloride
• CAS NO: 54260-89-8
• Molecular Formula: C₇H₈N₂O₂*ClH
• Molecular Weight: 188.61156
• EINECS: 259-047-2
• Mol File: 54260-89-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 373.4°Cat760mmHg
• Flash Point: 179.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 8.96E-06mmHg at 25°C
• CAS DataBase Reference: methyl (E)-3-(1H-imidazol-4-yl)acrylate monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-3-(1H-imidazol-4-yl)acrylate monohydrochloride(54260-89-8)
• EPA Substance Registry System: methyl (E)-3-(1H-imidazol-4-yl)acrylate monohydrochloride(54260-89-8)

Safety Data

• Hazardous Substances Data: 54260-89-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8N2O2.ClH/c1-11-7(10)3-2-6-4-8-5-9-6;/h2-5H,1H3,(H,8,9);1H/b3-2+;

Upstream product

• 67-56-1 methanol 
• 3465-72-3 urocanic Acid 
• 3465-72-3 (E)-3-(1H-imidazol-4-yl)propenoic acid 

Downstream Products

• 138408-36-3 trans-1-trityl-4-imidazoleacrylic acid methyl ester 
• 53958-94-4 3-(1H-imidazol-4-yl)propionic acid methyl ester hydrochloride 
• 70346-51-9 (E)-methyl 3-(1H-imidazol-4-yl)acrylate 
• 31434-93-2 methyl 3-(4-imidazolyl)propionate 
• 775350-40-8 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester 
• 52237-35-1 3-(1H-imidazol-5-yl)propan-1-ol monohydrobromide 
• 220377-96-8 ethyl (2E)-5-(1-triphenylmethyl-1H-imidazol-4-yl)pent-2-enoate 
• 102676-61-9 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde 
• 102676-60-8 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanoic acid methyl ester 
• 102676-68-6 ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pentanoate 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 220377-99-1 5-(1-trityl-1H-imidazol-4-yl)pentan-1-ol 
• 40546-33-6 3-[imidazol-4⁽⁵⁾-yl]propylamine 
• 138408-37-4 1-(triphenylmethyl)-4-(3-hydroxyprop-1-enyl)imidazole 

Relevant articles and documents

3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF

The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.

New high affinity H3 receptor agonists without a basic side chain

In this study, we replaced the basic amine function of the known histamine H3 receptor agonists imbutamine or immepip with non-basic alcohol or hydrocarbon moieties. All compounds in this study show a moderate to high affinity for the cloned human H3 receptor and, unexpectedly, almost all of them act as potent agonists. Moreover, in the alcohol series, we consistently observed an increased selectivity for the human H3 receptor over the human H4 receptor, but none of the compounds in this series possess increased affinity and functional activity compared to their alkylamine congeners. In this new series of compounds VUF5657, 5-(1H-imidazol-4-yl)-pentan-1-ol, is the most potent histamine H3 receptor agonist (pKi = 8.0 and pEC50 = 8.1) with a 320-fold selectivity at the human H3 receptor over the human H 4 receptor.

Inhibitors of prenyl-protein transferase

The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.