138984-17-5

Basic information

• Product Name: Butanamide, 2-diazo-N-(1,1-dimethylethyl)-3-oxo-N-(2-phenylethyl)-
• CAS NO: 138984-17-5
• Molecular Formula: C16H21N3O2
• Molecular Weight: 287.362
• Mol File: 138984-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-diazo-N-(1,1-dimethylethyl)-3-oxo-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-diazo-N-(1,1-dimethylethyl)-3-oxo-N-(2-phenylethyl)-(138984-17-5)
• EPA Substance Registry System: Butanamide, 2-diazo-N-(1,1-dimethylethyl)-3-oxo-N-(2-phenylethyl)-(138984-17-5)

Safety Data

• Hazardous Substances Data: 138984-17-5(Hazardous Substances Data)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 103-63-9 1-phenyl-2-bromoethane 
• 24070-10-8 2-methyl-N-phenethylpropan-2-amine 
• 151813-49-9 N-tert-butyl-N-(2-phenylethyl)acetoacetamide 

Downstream Products

• 1095537-42-0 C₁₆H₂₁NO₂ 
• 1095537-36-2 C₁₆H₂₁NO₂ 
• 1095537-48-6 C₁₅H₂₃NO 
• 1095537-29-3 C₁₇H₃₀NO₃P 
• 138984-08-4 N-tert-butyl-4-phenyl-2-pyrrolidone 
• 138984-02-8 N-tert-butyl-N-(2-phenylethyl)diazoacetamide 

Relevant articles and documents

Regio- and Enantioselective Intramolecular Amide Carbene Insertion into Primary C-H Bonds Using Ru(II)-Pheox Catalyst

We have established a method for the highly regio- and enantioselective functionalization of tert-butyl groups via intramolecular amide carbene insertion into C-H bonds, yielding γ-lactams with 91% ee in up to 99% yield. This reaction uses a ruthenium(II) phenyl oxazoline (Ru(II)-Pheox) complex. The catalytic intramolecular carbene transfer reaction to the primary C-H bond proceeds rapidly and selectively compared to that with secondary C-H, benzylic secondary C-H, tert-C-H, or sp2C-H bonds in the presence of 1 mol % Ru(II)-Pheox catalyst. This is the first example of a catalytic carbenoid insertion into an unactivated tert-butyl group with enantiocontrol at the carbenoid carbon.