13908-56-0 Usage
Description
1-(2-chloroethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)urea, also known as chloroethylphenylurea, is a chemical compound with the molecular formula C12H15ClN2O. It is a urea derivative that contains a chloroethyl group and a tetrahydronaphthalene ring. 1-(2-chloroethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)urea is recognized for its role in the synthesis of pharmaceuticals and agrochemicals, where it demonstrates the ability to inhibit plant growth and development. Additionally, it serves as a starting material for a variety of organic syntheses. Due to its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system, it is crucial to handle this chemical with care.
Uses
Used in Pharmaceutical Synthesis:
1-(2-chloroethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)urea is used as an intermediate in the pharmaceutical industry for the development of various drugs. Its unique chemical structure allows it to be a key component in the creation of molecules with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-chloroethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)urea is utilized as a growth regulator, where it helps control and inhibit plant growth and development. This application is particularly useful in the development of herbicides and other products aimed at managing plant growth.
Used in Organic Syntheses:
1-(2-chloroethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)urea also serves as a starting material in organic chemistry, where it can be used to synthesize a range of compounds with different applications, from specialty chemicals to advanced materials. Its versatility in organic synthesis makes it a valuable compound in the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 13908-56-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,0 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13908-56:
(7*1)+(6*3)+(5*9)+(4*0)+(3*8)+(2*5)+(1*6)=110
110 % 10 = 0
So 13908-56-0 is a valid CAS Registry Number.
13908-56-0Relevant articles and documents
Selective alkylation of βII-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents
Fortin, Jessica S.,Cote, Marie-France,Lacroix, Jacques,Desjardins, Michel,Petitclerc, Eric,C.-Gaudreault, Rene
, p. 7277 - 7290 (2008/12/22)
Aryl chloroethylureas (CEUs) are potent anti-neoplastic agents alkylating specific intracellular proteins such as βII-tubulin. Recently we have identified a new subset of CEU derived from compound 36 that alkylates thioredoxin isoform 1 (Trx-1), inhibits the nuclear translocation of Trx-1, and favors the accumulation of cells in G0/G1 phase. We have evaluated the effects of various substituents and their position on the aromatic ring of a series of derivatives of 36 on (i) the anti-proliferative activity, (ii) the cell cycle progression, (iii) the nuclear translocation of Trx-1, and (iv) their covalent binding to β-tubulin. The same experiments were performed on representative CEU derivatives where the 2-chloroethyl amino moiety is replaced by either an ethyl, a 2-aminooxazolinyl or a 2-chloroacetyl group. On one hand, our results suggest that CEUs substituted on the phenyl ring at position 3 or 4 by cycloalkyl and substituted cycloalkyl or cycloalkoxy groups inhibit the nuclear translocation of Trx-1 and arrest the cell cycle progression in G0/G1. On the other hand, CEUs substituted by a fused aromatic ring, an aliphatic chain, or a fused aliphatic ring are alkylating βII-tubulin but not Trx-1. Beside the expected inactivity of the ethylurea derivatives, none of the modification to the electrophilic moiety led to cross-selectivity of the drugs toward β-tubulin but increased the anti-proliferative activity and resulted in mitigated effects on Trx-1 translocation.
