140834-91-9

Basic information

• Product Name: BOC-Leu-Phe-O-benzyl
• Synonyms: BOC-Leu-Phe-O-benzyl
• CAS NO: 140834-91-9
• Molecular Weight: 0
• Mol File: 140834-91-9.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: BOC-Leu-Phe-O-benzyl(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-Leu-Phe-O-benzyl(140834-91-9)
• EPA Substance Registry System: BOC-Leu-Phe-O-benzyl(140834-91-9)

Safety Data

• Hazardous Substances Data: 140834-91-9(Hazardous Substances Data)

Upstream product

• 3392-09-4 Boc-Leu-ONSu 
• 1738-78-9 L-phenylalanine benzyl ester p-toluene-sulfonic acid salt 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 
• 100-51-6 benzyl alcohol 
• 2688-22-4 Nps-L-Phe-OH 
• 84673-44-9 (S)-2-(2-Nitro-phenylsulfanylamino)-3-phenyl-propionic acid benzyl ester 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 962-39-0 L-Phenylalanine benzyl ester 
• 61-90-5 L-leucine 
• 63-91-2 L-phenylalanine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 16937-99-8 N-Boc-D-Leu 

Downstream Products

• 70691-56-4 L-leucyl-L-phenylalanine methyl ester hydrochloride 
• 1365292-39-2 L-isoseryl-L-leucyl-L-phenylalanine benzyl ester hydrochloride 
• 1365292-52-9 L-isoseryl-L-leucyl-L-phenylalanine hydrochloride 
• 868540-15-2 (S)-benzyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 
• 868540-17-4 carfilzomib 
• 868540-16-3 (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid 
• 875309-92-5 (S)-benzyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoate 
• 70637-28-4 (S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt 
• 70637-29-5 Boc-Met-Leu-Phe-OCH₂C₆H₅ 
• 70637-32-0 formyl-Met-Leu-Phe-OCH₂C₆H₅ 
• 70637-30-8 H-Met-Leu-Phe-O-CH₂C₆H₅ 
• 59880-97-6 formyl-methionyl-leucyl-phenylalanine 
• 859-45-0 N-trifluoroacetyl-leucylphenylalanine methylester 

Relevant articles and documents

Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy to Overcome Cancer Resistance to Carfilzomib and Bortezomib

Over the past 15 years, proteasome inhibitors (PIs), namely bortezomib, carfilzomib (Cfz) and ixazomib, have significantly improved the overall survival and quality-of-life for multiple myeloma (MM) patients. However, a significant portion of MM patients do not respond to PI therapies. Drug resistance is present either de novo or acquired after prolonged therapy through mechanisms that remain poorly defined. The lack of a clear understanding of clinical PI resistance has hampered the development of next-generation PI drugs to treat MM patients who no longer respond to currently available therapies. Here, we designed and synthesized novel epoxyketone-based PIs by structural modifications at the P1′ site. We show that a Cfz analog, 9, harboring a hydroxyl substituent at its P1′ position was highly cytotoxic against cancer cell lines displaying de novo or acquired resistance to Cfz. These results suggest that peptide epoxyketones incorporating P1′-targeting moieties may have the potential to bypass resistance mechanisms associated with Cfz and to provide additional clinical options for patients resistant to Cfz.

A cytochrome c-urea functionalized dipeptide conjugate: An efficient HBD framework to synthesize 4: H -pyrans via one-pot multicomponent reaction

This work is focused on the development of an efficient and green protocol for the one-pot multicomponent synthesis of a series of 4H-pyran derivatives. Herein, a protein-peptide conjugate (SS1-Cyt. c) is synthesized and characterized using Circular Dichr

The greening of peptide synthesis

The synthesis of peptides by amide bond formation between suitably protected amino acids is a fundamental part of the drug discovery process. However, the required coupling and deprotection reactions are routinely carried out in dichloromethane and DMF, b