16937-99-8

Basic information

• Product Name: BOC-D-Leucine monohydrate
• Synonyms: N-(TERT-BUTOXYCARBONYL)-D-LEUCINE;N-ALPHA-T-BOC-D-LEUCINE;BOC-D-LEU-OH;BOC-D-LEUCINE;L-LEUCINE-5,5,5-D3, N-T-BOC DERIV.H20 98;N-T-BOC-D-LEUCINE;N-TERT-BUTOXYCARBONYL-D-LEUCINE 1-HYDRATE;Boc-D-Leu-OH hydrate
• CAS NO: 16937-99-8
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 249.3
• EINECS: 1312995-182-4
• Product Categories: Amino Acids;Leucine [Leu, L];Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series
• Mol File: 16937-99-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 85-87 °C(lit.)
• Boiling Point: 356 °C at 760 mmHg
• Flash Point: 169.1 °C
• Appearance: white fine crystals
• Density: 1.061 g/cm3
• Vapor Pressure: 4.98E-06mmHg at 25°C
• Refractive Index: 25 ° (C=2, AcOH)
• Storage Temp.: −20°C
• Solubility: Acetic Acid (Sparingly), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.02±0.21(Predicted)
• BRN: 2331060
• CAS DataBase Reference: BOC-D-Leucine monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-Leucine monohydrate(16937-99-8)
• EPA Substance Registry System: BOC-D-Leucine monohydrate(16937-99-8)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 16937-99-8(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline

Uses

N-Boc-D-leucine is an N-Boc-protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.

InChI:InChI=1/C11H21NO4.H2O/c1-7(2)6-8(9(13)14)12-10(15)16-11(3,4)5;/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14);1H2/t8-;/m1./s1

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 328-38-1 (R)-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 129568-83-8 (2R,2'R)-N-(2'-amino-4'-methylpentanoyl)bornane-10,2-sultam 
• 19792-08-6 p-nitrophenyl-N-(t-butoxycarbonyl)-D-leucinate 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 145123-00-8 (2R,2'R)-N-<2'-<<(tert-butoxy)carbonyl>amino>-4'-methylbutanoyl>bornane-10,2-sultam 
• 170642-24-7 (R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 54594-06-8 D-allylglycine 
• 106930-51-2 tert-butyl [(2R)-1-hydroxy-4-methylpentan-2-yl]carbamate 
• 69805-63-6 methyl 2-((tert-butoxycarbonyl)amino)-4-methylpentanoate 
• 756498-96-1 ethyl N-tert-butyloxycarbonyl-2-amino-4-methyl-pentanoate 
• 73371-96-7 2-<<(tert-butoxycarbonyl)oxy>imino>-2-phenylacetonitrile 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 

Downstream Products

• 60654-42-4 Boc-D-Leu-NH-NH-Z 
• 116300-00-6 1-diazo-3(R)-<<(1,1-dimethylethoxy)carbonyl>amino>-5-methyl-2-hexanone 
• 83160-12-7 N^α-Tos-D-Lys-Gly-Phe-D-Leu-OH 
• 73401-70-4 Boc-Leu-OMPA 
• 78834-53-4 BOC-D-Leu-L-Val-pNA 
• 140834-91-9 Boc-D-Leu-Phe-OBzl 
• 137022-74-3 Boc-D-Leu-Gly-NHOBzl 
• 137029-92-6 [(R)-1-((S)-1-Benzyl-2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 137005-62-0 {(R)-1-[(S)-1-Benzyl-2-oxo-2-(4-phenyl-piperidin-1-yl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 137005-63-1 {(R)-1-[(S)-1-Benzyl-2-oxo-2-(4-phenyl-piperazin-1-yl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 137005-64-2 ((R)-1-{(S)-2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-1-benzyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid tert-butyl ester 
• 137005-65-3 {(R)-1-[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 77302-94-4 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((R)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester 
• 77302-93-3 (R)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((R)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

Synthetic studies of dideminus. III. Syntheses of statine and isostatine stereoisomers

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Optical resolution of N-(t-butoxycarbonyl)leucine through mixed ligand complex formation with (R)-N-(2-pyridylmethyl)pipecolatocopper(II)

A copper(II) complex of (R)-N-(2-pyridylmethyl)pipecolate (pmpi) was prepared, and its structure was revealed by X-ray crystal structure analysis. Mixed ligand complexes were then prepared from this complex and (R)- and (S)-N-(t-butoxycarbonyl)leucinate (BocLeu). The (R)-BocLeu complex is less soluble in aqueous acetonitrile and more soluble in acetone than the (S)-BocLeu complex, and the reason was discussed on the basis of their structures. Recrystallization of the reaction mixture consisting of Cu(II) ion, pmpi, and (RS)-BocLeu from aqueous acetonitrile gave the (R)-BocLeu complex and that from acetone gave the (S)-BocLeu complex.

PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.