141333-36-0

Basic information

• Product Name: 2-(3-(cyclopentyloxy)-4-Methoxyphenyl)acetonitrile
• Synonyms: 2-(3-(cyclopentyloxy)-4-Methoxyphenyl)acetonitrile;2-(3-Cyclopentyloxy-4-methoxyphenyl)ethanenitrile;3-(Cyclopentyloxy)-4-methoxybenzeneacetonitrile;3-Cyclopentyloxy-4-methoxyphenylacetonitrile
• CAS NO: 141333-36-0
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.29028
• Mol File: 141333-36-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 32-34℃
• Boiling Point: 371℃
• Flash Point: 135℃
• Appearance: /
• Density: 1.109
• CAS DataBase Reference: 2-(3-(cyclopentyloxy)-4-Methoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(cyclopentyloxy)-4-Methoxyphenyl)acetonitrile(141333-36-0)
• EPA Substance Registry System: 2-(3-(cyclopentyloxy)-4-Methoxyphenyl)acetonitrile(141333-36-0)

Safety Data

• Hazardous Substances Data: 141333-36-0(Hazardous Substances Data)

Usage

General Description

2-(3-(cyclopentyloxy)-4-methoxyphenyl)acetonitrile is a chemical compound with the molecular formula C15H17NO2. It is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, which is associated with pain perception. 2-(3-(cyclopentyloxy)-4-methoxyphenyl)acetonitrile has shown potential in the treatment of chronic pain conditions, as it is able to selectively block the transmission of pain signals in the nervous system. Additionally, it has demonstrated promising pharmacological properties, such as high potency and good selectivity, making it a valuable candidate for the development of new analgesic medications.

Upstream product

• 143-33-9 sodium cyanide 
• 141333-35-9 α-bromo-3-cyclopentyloxy-4-methoxytoluene 
• 151-50-8 potassium cyanide 
• 175206-66-3 4-chloromethyl-2-cyclopentyloxy-1-methoxybenzene 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 133332-49-7 (3-cyclopentyloxy-4-methoxyphenyl)methanol 
• 75-77-4 chloro-trimethyl-silane 
• 3277-26-7 1,1,3,3-Tetramethyldisiloxane 
• 773837-37-9 sodium cyanide 

Downstream Products

• 152630-48-3 dimethyl 4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)pimelate 
• 183660-31-3 1-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclopropanecarbonitrile 
• 141332-75-4 2-(3-cyclopentyloxy-4-methoxyphenyl)ethylamine 
• 401518-81-8 1-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclopen-3-ene-1-carbonitrile 
• 401518-12-5 tert-butyl 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidine-1-carboxylate 
• 752259-53-3 (3aR,7aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2,3,3a,4,7,7a-hexahydro-1H-indene-2-carbonitrile 
• 401518-83-0 2-(3-cyclopentyloxy-4-methoxyphenyl)-4-oxo-2-(2-oxoethyl)butanenitrile 
• 401518-91-0 2-(4-(3-cyclopentyloxy-4-methoxyphenyl)-4-cyanopiperidin-1-yl)-2-methylpropanoic acid 
• 401518-92-1 1-(4-(3-cyclopentyloxy-4-methoxyphenyl)-4-cyanopiperidin-1-yl)cyclopropanecarboxylic acid 
• 401518-84-1 benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate 
• 401518-85-2 benzyl 1-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}cyclopropanecarboxylate 
• 828919-77-3 (3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile 
• 439919-54-7 (2s,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile 
• 440103-31-1 (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile 

Relevant articles and documents

Repurposing human PDE4 inhibitors for neglected tropical diseases: Design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors

A medicinal chemistry exploration of the human phosphodiesterase 4 (hPDE4) inhibitor cilomilast (1) was undertaken in order to identify inhibitors of phosphodiesterase B1 of Trypanosoma brucei (TbrPDEB1). T. brucei is the parasite which causes African sleeping sickness, a neglected tropical disease that affects thousands each year, and TbrPDEB1 has been shown to be an essential target of therapeutic relevance. Noting that 1 is a weak inhibitor of TbrPDEB1, we report the design and synthesis of analogs of this compound, culminating in 12b, a sub-micromolar inhibitor of TbrPDEB1 that shows modest inhibition of T. brucei proliferation.

METHOD FOR PREPARING SUBSTITUTED 4-PHENYL-4-CYANOCYCLOHEXANOIC ACIDS

This invention relates to a method of preparing a compound type where at least one of R′ or R″ is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and wa

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory activity after topical administration as well as their gastro-intestinal side effects. Several compounds proved to be potent PDE4 inhibitors and some 2-cyanoiminoimidazoles showed less pronounced gastro-intestinal side effects than reference compounds but maintained anti-inflammatory activity after topical administration.