440103-31-1

Basic information

• Product Name: (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile
• Synonyms: (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile
• CAS NO: 440103-31-1
• Molecular Weight: 339.434
• Mol File: 440103-31-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile(440103-31-1)
• EPA Substance Registry System: (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile(440103-31-1)

Safety Data

• Hazardous Substances Data: 440103-31-1(Hazardous Substances Data)

Upstream product

• 752259-54-4 dimethyl 2,2'-[(1R,2S)-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclopentane-1,2-diyl]diacetate 
• 141333-36-0 4-cyanomethyl-2-cyclopentyloxy-1-methoxybenzene 
• 828919-96-6 [(1R,2S)-2-Carboxymethyl-4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclopentyl]-acetic acid 
• 828919-77-3 (3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile 
• 752259-53-3 (3aR,7aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2,3,3a,4,7,7a-hexahydro-1H-indene-2-carbonitrile 

Downstream Products

• 439919-55-8 (2r,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-(1,3-dithian-2-ylidene)octahydropentalene-2-carbonitrile 
• 440103-34-4 methyl (2r,3aR,5s,6aS)-5-cyano-5-[3-(cyclopentyloxy)-4-methoxyphenyl]octahydropentalene-2-carboxylate 
• 440103-35-5 methyl (2s,3aR,5s,6aS)-5-cyano-5-[3-(cyclopentyloxy)-4-methoxyphenyl]octahydropentalene-2-carboxylate 

Relevant articles and documents

Orally active PDE4 inhibitors with therapeutic potential

Based on the successful results in the clinical trial of Ariflo, further optimization of the spatial arrangement of the three pharmacophores (carboxylic acid moiety, nitrile moiety and 3-cyclopentyl-4-methoxyphenyl moiety) in the structure of Ariflo 1 was