143329-81-1

Basic information

• Product Name: α,α'-dimethyl-1,3-benzenedimethanol
• Synonyms: α,α'-dimethyl-1,3-benzenedimethanol
• CAS NO: 143329-81-1
• Molecular Weight: 166.22
• Mol File: 143329-81-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: α,α'-dimethyl-1,3-benzenedimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α,α'-dimethyl-1,3-benzenedimethanol(143329-81-1)
• EPA Substance Registry System: α,α'-dimethyl-1,3-benzenedimethanol(143329-81-1)

Safety Data

• Hazardous Substances Data: 143329-81-1(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 626-19-7 Isophthalaldehyde 
• 6781-42-6 1,3-diacetylbenzene 
• 1785-61-1 1,3-diethynylbenzene 
• 3748-13-8 1,3-bis(1-methylethenyl)-benzene 
• 75-16-1 methylmagnesium bromide 
• 143329-81-1 α,α'-dimethyl-1,3-benzenedimethanol 
• 108-22-5 Isopropenyl acetate 
• 143329-84-4 (R,R)-α,α'-dimethyl-1,3-benzenedimethanol diacetate 
• 108-57-6 1,3-divinylbenzene 
• 1325730-34-4 1,3-bis((S)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)benzene 
• 97-72-3 2-Methylpropionic anhydride 

Downstream Products

• 6781-42-6 1,3-diacetylbenzene 
• 861081-16-5 1,3-bis-(1-bromo-ethyl)-benzene 
• 33076-39-0 α,α'-dimethyl-1,3-benzenedimethanol diacetate 
• 143329-84-4 (R,R)-α,α'-dimethyl-1,3-benzenedimethanol diacetate 
• 6781-44-8 (R,R)-α,α'-dimethyl-1,3-benzenedimethanol 
• 19247-97-3 α,α'-dibromo-1,3-diacetylbenzene 
• 3049-10-3 1,3-dioxoacetyl-benzene 
• 1291093-60-1 C₁₀H₁₆ 
• 114468-31-4 (E,E)-1,3-Bis<2-(4-methoxyphenyl)ethenyl>benzol 
• 67-63-0 isopropyl alcohol 

Relevant articles and documents

Multi-substituted chiral (1 - hydroxyethyl) benzene and asymmetric synthesis method thereof

The invention relates to polysubstituted chiral (1-ethoxy)benzene. The specific structure of the polysubstituted chiral (1-ethoxy)benzene is as shown in a formula II. The invention also discloses a 'two-step one-pot' synthetic method of the polysubstituted chiral (1-ethoxy)benzene. The 'two-step one-pot' synthetic method is characterized by taking polyacetylenyl substituted benzene (I) as a raw material, and comprises the following steps: step (1) taking fluorine-containing alcohol and water as solvents, carrying out hydration reaction under the catalysis of trifluoromethanesulfonic acid, thusgenerating an intermediate-ketone; step (2) directly adding a complex of mono-sulfonyl chiral diamine and metal ruthenium, rhodium or iridium as a catalyst in a reaction system, adding alkali, supplementing hydrogen, and carrying out asymmetric hydrogenation reaction, thus obtaining a product II; or directly adding the complex of the mono-sulfonyl chiral diamine and the metal ruthenium, rhodium or iridium as the catalyst in the reaction system, using a mixture of sodium formate or formic acid and triethylamine as a hydrogen source, and carrying out the asymmetric transfer hydrogenation reaction, thus obtaining the product II. According to the 'two-step one-pot' synthetic method disclosed by the invention, the operation is simple, the raw material is easy to obtain, and enantioselectivityand diastereoselectivity are very high. (The formula II is shown in the description).

One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis

A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF3SO3H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF3CH2OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.

Advantageous asymmetric ketone reduction with a competitive hydrogenation/transfer hydrogenation system using chiral bifunctional iridium catalysts

Hydrogenation of aromatic ketones with chiral bifunctional amidoiridium complexes proceeds in preference to transfer hydrogenation in methanol, in which the pressurised hydrogen can suppress unintended racemisation of the alcoholic product, leading to enh