143699-92-7Relevant articles and documents
Synthesis and biological evaluation of novel azetidine derivatives as dopamine antagonist
Metkar, Shashikant D.,Bhatia, Manish S.,Desai, Uday V.
, p. 5982 - 5989 (2013)
In this study, azetidine derivatives were evaluated for their potency as dopaminergic antagonist. The study comprised derivatives substituted in 3-position with amide moiety. Further, the phenyl moiety of amide was modified at 2, 3, or 4-position. The substituted compounds were biologically evaluated for their affinity for D2 and D4 receptors. The most potent D2 and D4 antagonist among these compounds appeared to be the N-(1-benzhydryl-azetidin-3yl)-2-bromo-benzamide and N-(1-benzhydryl-azetidin-3yl)-4-bromo-benzamide, respectively. Various docking interactions of CPPMA with the D4 receptor and the same for compound 5 i.e., N-(1-benzhydryl-azetidin-3yl)-4-bromo-benzamide were found to have good correlation with observed biological activity.
Aminoheteroaryl compounds and preparation method and use thereof
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Paragraph 0151; 0152, (2014/12/09)
The present invention refers to aminoheteroaryl compounds of the following formula (I) as well as the preparation method and use thereof, wherein R1 and R3 are defined in the Description in details. The aminoheteroaryl compounds of t
PYRAZOLE DERIVATIVE
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Page/Page column 67, (2008/06/13)
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