40432-52-8

Basic information

• Product Name: 3-Amino-1-diphenylmethylazetidine
• Synonyms: 3-AMINO-1-DIPHENYLMETHYLAZETIDINE;1-BENZHYDRYL-AZETIDIN-3-YLAMINE;1-BENZHYDRYL-3-AMINOAZETIDINE;1-BENZHYDRYLAZETIDIN-3-AMINE;BUTTPARK 92\50-95;3-amino-1-benzhylazetidine;3-AMINO-1-BENZHYDRYLAZETIDINE;3-Amino-1-Diphenylmethylazetid
• CAS NO: 40432-52-8
• Molecular Formula: C₁₆H₁₈N₂
• Molecular Weight: 238.33
• EINECS: 1312995-182-4
• Product Categories: Amines;Azetidines;Ring Systems
• Mol File: 40432-52-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 63 °C
• Boiling Point: 339.2 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: White powder
• Density: 1.125 g/cm³
• Vapor Pressure: 9.32E-05mmHg at 25°C
• Refractive Index: 1.621
• PKA: 8.48±0.20(Predicted)
• CAS DataBase Reference: 3-Amino-1-diphenylmethylazetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-1-diphenylmethylazetidine(40432-52-8)
• EPA Substance Registry System: 3-Amino-1-diphenylmethylazetidine(40432-52-8)

Safety Data

• Hazardous Substances Data: 40432-52-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C16H18N2/c17-15-11-18(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-16H,11-12,17H2

Upstream product

• 38353-74-1 2-(1-benzhydrylazetidin-3-yl)isoindoline-1,3-dione 
• 143699-92-7 3-Azido-1-benzhydryl-azetidine 
• 91189-18-3 tert-butyl (1-benzhydrylazetidin-3-yl)carbamate 
• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 1375075-83-4 C₁₆H₁₆N₂O*ClH 
• 40320-60-3 N-benzhydryl 3-azetidinone 
• 91-00-9 Benzhydrylamine 
• 63477-43-0 3-chloro-1-diphenylmethylamino-2-hydroxypropane 

Downstream Products

• 102065-87-2 N-(1-benzhydryl-azetidin-3-yl)-acetamide 
• 510729-14-3 (1-benzhydryl-azetidin-3-yl)-(2-fluoro-4-nitro-phenyl)-amine 
• 817555-03-6 N-[1-(diphenylmethyl)-3-azetidinyl]methanesulfonamide 
• 91189-18-3 tert-butyl (1-benzhydrylazetidin-3-yl)carbamate 
• 256526-41-7 (2S)-N₂-(1-diphenylmethyl-3-azetidinyl)-1-(1,3-benzoxazol-2-yl)-2-piperidinecarboxamide 
• 132920-58-2 ethyl 1-(1-diphenylmethylazetidin-3-yl)-6,7-difluoro-1,4-dihydro-4-oxoquinolin-3-carboxylate 
• 321344-94-9 1-(1-diphenylmethylazetidin-3-yl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrole 
• 337511-57-6 1-(diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine 
• 942308-13-6 1-benzhydryl-3-(N,N-dicyclopropylamino)-3-azetidine 
• 893565-91-8 C₅₉H₈₇N₃O₁₅ 

Relevant articles and documents

Synthesis and biological evaluation of novel azetidine derivatives as dopamine antagonist

In this study, azetidine derivatives were evaluated for their potency as dopaminergic antagonist. The study comprised derivatives substituted in 3-position with amide moiety. Further, the phenyl moiety of amide was modified at 2, 3, or 4-position. The substituted compounds were biologically evaluated for their affinity for D2 and D4 receptors. The most potent D2 and D4 antagonist among these compounds appeared to be the N-(1-benzhydryl-azetidin-3yl)-2-bromo-benzamide and N-(1-benzhydryl-azetidin-3yl)-4-bromo-benzamide, respectively. Various docking interactions of CPPMA with the D4 receptor and the same for compound 5 i.e., N-(1-benzhydryl-azetidin-3yl)-4-bromo-benzamide were found to have good correlation with observed biological activity.

MACROLIDES

The invention relates to compounds of Formula (I): wherein R1, R2 and X are as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of Formula (I).

DIRECT AMINOLYSIS

In some aspects, the present invention provides a method of preparing a compound of the formula (I) comprising reacting a mesylate compound of the formula (II) by direct aminolysis with a reagent comprising ammonia. The reaction is preferably carried out