14387-10-1

Basic information

• Product Name: 2-(4-ethylphenyl)acetic acid
• Synonyms: 2-(4-ethylphenyl)acetic acid;(4-ethylphenyl)acetic acid;benzeneacetic acid, 4-ethyl-;4-Ethylbenzeneacetic acid;(4-ethylphenyl)acetic acid(SALTDATA: FREE);2-(4-ethylphenyl)ethanoic acid
• CAS NO: 14387-10-1
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.21
• Mol File: 14387-10-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 186.4 °C
• Appearance: /
• Density: 1.096 g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C
• PKA: pK1:4.373 (25°C)
• CAS DataBase Reference: 2-(4-ethylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethylphenyl)acetic acid(14387-10-1)
• EPA Substance Registry System: 2-(4-ethylphenyl)acetic acid(14387-10-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14387-10-1(Hazardous Substances Data)

Usage

Description

2-(4-ethylphenyl)acetic acid, also known as (4-Ethylphenyl)acetic acid, is an organic compound with the molecular formula C10H12O2. It is a colorless to pale yellow crystalline solid and is a derivative of acetic acid with an ethylphenyl group attached to the 2nd carbon. 2-(4-ethylphenyl)acetic acid is characterized by its aromatic properties and is used as a reagent in the chemical synthesis of various compounds.

Uses

Used in Pharmaceutical Industry:
2-(4-ethylphenyl)acetic acid is used as a reagent for the synthesis of p-Ethylhydratropic Acid (E918820), which is an impurity found in the production of ibuprofen (I140000). Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that helps in reducing pain, inflammation, and fever. The synthesis of p-Ethylhydratropic Acid is essential for maintaining the purity and quality of ibuprofen, ensuring its effectiveness and safety for medical use.

InChI:InChI=1/C10H12O2/c1-2-8-3-5-9(6-4-8)7-10(11)12/h3-6H,2,7H2,1H3,(H,11,12)

Upstream product

• 18640-62-5 1-allyl-4-ethylbenzene 
• 10408-52-3 (rac)-2-(4-ethylphenyl)-2-hydroxyacetic acid 
• 51632-28-1 (4-ethyl-phenyl)-acetonitrile 
• 77062-85-2 ethyl 2-(4-ethylphenyl)-2-hydroxyacetate 
• 14182-64-0 2-(4-ethylphenyl)-1-morpholin-4-yl-ethanethione 
• 1528-42-3 ethyl 4-acetylphenylacetate 
• 1467-05-6 4-ethylbenzylchloride 
• 50690-09-0 2-chloro-1-(4-ethylphenyl)ethan-1-one 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 7601-90-3 perchloric acid 
• 46122-65-0 4-vinylbenzeneacetic acid 
• 100-41-4 ethylbenzene 
• 101-97-3 Ethyl 2-phenylethanoate 

Downstream Products

• 102702-68-1 (4-ethyl-phenyl)-acetic acid dodecyl ester 
• 22545-13-7 2-(4'-ethylphenyl)ethanol 
• 14062-20-5 ethyl (4-ethyl-phenyl)-acetate 
• 36207-10-0 (4-Ethyl-phenyl)-acetic acid methyl ester 
• 127035-73-8 4-[(E)-2-(4-Ethyl-phenyl)-vinyl]-2,6-dimethyl-phenol 
• 52629-43-3 4-Ethylphenylessigsaeurechlorid 
• 609352-24-1 Bromo-(4-ethyl-phenyl)-acetic acid methyl ester 
• 518976-74-4 1-Ethyl-4-isocyanatomethyl-benzene 
• 143818-88-6 4-[3,3-Diethyl-1-(4-ethyl-benzylcarbamoyl)-4-oxo-azetidin-2-yloxy]-benzoic acid 
• 792971-31-4 4-(ethyl)-phenyl-ethanoic acid tributyltin ester 
• 394207-67-1 C₁₃H₁₆O₄ 
• 441797-35-9 C₁₉H₁₉ClN₄O₂S 
• 441795-37-5 C₂₁H₂₄N₄O₄S 
• 146533-39-3 4,6-dichloro-5-(4-ethyl-phenyl)-pyrimidine 

Relevant articles and documents

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A General, Activator-Free Palladium-Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid

A new catalyst for the carboxylative synthesis of arylacetic and benzoic acids using formic acid (HCOOH) as the CO surrogate was developed. In an improvement over previous work, CO is generated in situ without the need for any additional activators. Key to success was the use of a specific system consisting of palladium acetate and 1,2-bis((tert-butyl(2-pyridinyl)phosphinyl)methyl)benzene. The generality of this method is demonstrated by the synthesis of more than 30 carboxylic acids, including non-steroidal anti-inflammatory drugs (NSAIDs), under mild conditions in good yields.

Tri-n-butyltin carboxylate derivatives of para-substituted phenyl-ethanoic acids: Synthesis, characterization and X-ray structure determination

The tributyltin esters of 4-(ethyl)-phenyl-ethanoic acid and 4-(isopropyl)-phenyl-ethanoic acid have been prepared as model compounds of the repeating unit of the related stannylated polystyrenic derivatives. Both the products were fully characterized by proton and carbon NMR two-dimensional techniques. FT-IR spectra show in the solid state carboxylated moieties bridging R 3 Sn groups with the metal atom expanding its coordination number, this structure being destroyed in solution. The supramolecular arrangement of the products in the solid state has been investigated by X-ray diffraction, which confirms the pentacoordination at tin in both the products, and indicates a different spatial arrangement of the alkylated aryl groups, as evidenced also by the slightly different thermal properties.