1443118-44-2 Usage
Description
[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone is a complex organic compound characterized by its unique molecular structure. It is a derivative of phenyl and piperidinyl moieties, with a fluorine atom and an ethynyl linkage to a methoxyphenyl group. [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone holds potential for various applications in different industries due to its distinct chemical properties.
Uses
Used in Pharmaceutical Industry:
[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Chemical Research:
In the field of chemical research, [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone serves as a valuable compound for studying the properties and reactivity of complex organic molecules. It can be used to explore new reaction pathways and develop innovative synthetic methods.
Used in Material Science:
[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone may also find applications in material science, where its unique structural features can be exploited to create novel materials with specific properties. These materials could have potential uses in various industries, such as electronics or aerospace.
Used in Central Nervous System (CNS) Applications:
As a mGlu3 selective negative allosteric modulator with the ability to penetrate the central nervous system, [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone is used for the development of therapeutic agents targeting neurological disorders. Its ability to modulate glutamate signaling pathways can lead to potential treatments for conditions such as anxiety, schizophrenia, and neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1443118-44-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,1,1 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1443118-44:
(9*1)+(8*4)+(7*4)+(6*3)+(5*1)+(4*1)+(3*8)+(2*4)+(1*4)=132
132 % 10 = 2
So 1443118-44-2 is a valid CAS Registry Number.
1443118-44-2Relevant articles and documents
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)
Wenthur, Cody J.,Morrison, Ryan,Felts, Andrew S.,Smith, Katrina A.,Engers, Julie L.,Byers, Frank W.,Daniels, J. Scott,Emmitte, Kyle A.,Conn, P. Jeffrey,Lindsley, Craig W.
, p. 5208 - 5212 (2013/07/26)
A multidimensional, iterative parallel synthesis effort identified a series of highly selective mGlu3 NAMs with submicromolar potency and good CNS penetration. Of these, ML337 resulted (mGlu3 IC50 = 593 nM, mGlu2 IC50 >30 μM) with B:P ratios of 0.92 (mouse) to 0.3 (rat). DMPK profiling and shallow SAR led to the incorporation of deuterium atoms to address a metabolic soft spot, which subsequently lowered both in vitro and in vivo clearance by >50%.
