198976-43-1

Basic information

• Product Name: (R)-3-Hydroxypiperidine hydrocloride
• Synonyms: 3-PIPERIDINOL, HYDROCHLORIDE, (3R)-;3-PIPERIDINOL, HYDROCHLORIDE, (3S)-;(R)-(+)-3-PIPERIDINOL HYDROCHLORIDE;(R)-3-PIPERIDINOL HYDROCHLORIDE;(R)-(+)-3-HYDROXYPIPERIDINE HYDROCHLORIDE;(R)-3-HYDROXYPIPERIDINE HYDROCHLORIDE;(R)-3-HYDROXYPIPERIDINE HYDROCLORIDE;(R)-PIPERIDIN-3-OL HYDROCHLORIDE
• CAS NO: 198976-43-1
• Molecular Formula: C5H12ClNO
• Molecular Weight: 137.61
• EINECS: 264-644-6
• Product Categories: pharmacetical;Piperidine;API intermediates;Chiral;Piperidines;Chiral Building Blocks;Heterocyclic Building Blocks
• Mol File: 198976-43-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 195-196 °C(lit.)
• Boiling Point: 191.9 °C at 760 mmHg
• Flash Point: 104.5 °C
• Appearance: White/Crystalline Powder
• Vapor Pressure: 0.134mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water
• CAS DataBase Reference: (R)-3-Hydroxypiperidine hydrocloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Hydroxypiperidine hydrocloride(198976-43-1)
• EPA Substance Registry System: (R)-3-Hydroxypiperidine hydrocloride(198976-43-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36/7/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 198976-43-1(Hazardous Substances Data)

Usage

Description

(R)-3-Hydroxypiperidine hydrochloride is a white to light yellow crystal powder that serves as a crucial starting material in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the medical field.

Uses

Used in Pharmaceutical Industry:
(R)-3-Hydroxypiperidine hydrochloride is used as a starting material for the synthesis of (R)-(+)-3-pyrrolidyl benzilates, which have significant pharmaceutical applications. These synthesized compounds can be further utilized in the development of drugs targeting specific medical conditions, contributing to the advancement of therapeutic options.

InChI:InChI=1/C5H11NO.ClH/c7-5-2-1-3-6-4-5;/h5-7H,1-4H2;1H/t5-;/m1./s1

Upstream product

• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 
• 924651-55-8 tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate 
• 924651-52-5 allyl-(2-methoxymethoxy-but-3-enyl)-carbamic acid tert-butyl ester 
• 924651-53-6 3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1449318-65-3 1-benzyl-1H-pyrazol-4-carboxylic acid [5-bromo-4-((R)-3-hydroxypiperidin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 95798-22-4 3-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 1453499-57-4 (R)-5-benzyloxy-2-{2-[4-(3-hydroxy-piperidin-1-ylmethyl)-2-methyl-phenyl]-2-oxo-ethyl}-2H-pyridazin-3-one 
• 1448706-03-3 C₂₆H₂₇N₃OS 
• 1443118-44-2 [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone 
• 1443118-53-3 (R)-(3-hydroxypiperidin-1-yl)(4-((4-methoxyphenyl)ethynyl)phenyl)methanone 
• 1443118-47-5 (R)-(3-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone 
• 1246816-21-6 (+/-)-2-(3-hydroxypiperidin-1-yl)benzonitrile 
• 62367-59-3 (S)-3-hydroxy-1-methylpiperidine 
• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 
• 80613-04-3 3-hydroxypiperidine-1-carboxylic acid methyl ester 
• 121138-39-4 2-cyanoethyl 3-piperidinyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 73193-61-0 N-carbethoxy-3-piperidinol 

Relevant articles and documents

A new asymmetric synthetic route to substituted piperidines

An asymmetric synthesis of substituted piperidines has been described. β-Cyclodextrin- or oxazaborolidine-catalyzed asymmetric reduction of α-azido aryl ketones to the corresponding alcohols has been employed as the key step along with ring closing metathesis and selective dihydroxylation.